Journal
CHEM
Volume 1, Issue 1, Pages 127-146Publisher
CELL PRESS
DOI: 10.1016/j.chempr.2016.04.002
Keywords
-
Categories
Funding
- EPSRC [EP/J009687/1, EP/F03623X/1, EP/J00961X/1]
- Spanish government
- EU [FIS PI13/00089]
- La Marato de TV3 Foundation [20132730]
- Royal Society
- Wolfson Foundation
- University of Southampton
- China Scholarship Council
- EPSRC [EP/F03623X/1, EP/J00961X/1, EP/J009687/1, EP/K03927X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J00961X/1, EP/K03927X/1, EP/J009687/1, EP/F03623X/1] Funding Source: researchfish
Ask authors/readers for more resources
Synthetic transmembrane anion transporters (anionophores) have potential as tools for biomedical research and as therapeutic agents for diseases associated with anion-channel dysfunction. However, the possibility of H+ or OH- transport by anionophores has received little attention, and an anionophore selective for Cl- over H+/OH- is currently unavailable. Here, we show that depending on anionophore acidity, many anionophores facilitate electrogenic H+ or OH- transport, potentially leading to toxicity. Nevertheless, using several liposome-membrane-based assays, we identified two newly developed small molecules that promote electrogenic Cl- transport without effectively dissipating the transmembrane pH gradient, essentially mimicking the electrogenic cationophore valinomycin. The Cl- > H+/OH- selectivity of anionophores showed a consistent positive correlation with the degree of Cl- encapsulation and a negative correlation with the acidity of hydrogen-bond donors. Our study demonstrates that a valinomycin equivalent for Cl--selective transport is achievable.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available