Journal
AGING AND DISEASE
Volume 13, Issue 5, Pages 1405-1412Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2022.0216
Keywords
Parkinson's disease; pathogenesis; Nuclear; DNA damage; DNA repair
Categories
Funding
- National Natural Science Foundation of China [81771216]
- Key Research and Development Program of Zhejiang Province [2020C03020]
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This article summarizes the evidence for nuclear DNA damage in Parkinson's disease (PD) and discusses the molecular mechanisms of nuclear DNA damage and repair in PD, particularly from the perspective of familial PD-related mutant genes, emphasizing the significance of DNA damage and repair as potential intervention targets for treating PD.
Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of midbrain substantia nigra pars compacta dopaminergic neurons and the formation of Lewy bodies. Over the years, researchers have gained extensive knowledge about dopaminergic neuron degeneration from the perspective of the environmental and disease-causing genetic factors; however, there is still no disease-modifying therapy. Aging has long been recognized as a major risk factor for PD; however, little is known about how aging contributes to the disease development. Genome instability is the main driving force behind aging, and has been poorly studied in patients with PD. Here, we summarize the evidence for nuclear DNA damage in PD. We also discuss the molecular mechanisms of nuclear DNA damage and repair in PD, especially from the perspective of familial PD-related mutant genes. Understanding the significance of DNA damage and repair may provide new potential intervention targets for treating PD.
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