Involvement of Fatty Acids and Their Metabolites in the Development of Inflammation in Atherosclerosis

Despite all the advances of modern medicine, atherosclerosis continues to be one of the most important medical and social problems. Atherosclerosis is the cause of several cardiovascular diseases, which are associated with high rates of disability and mortality. The development of atherosclerosis is associated with the accumulation of lipids in the arterial intima and the disruption of mechanisms that maintain the balance between the development and resolution of inflammation. Fatty acids are involved in many mechanisms of inflammation development and maintenance. Endothelial cells demonstrate multiple cross-linkages between lipid metabolism and innate immunity. In addition, these processes are linked to hemodynamics and the function of other cells in the vascular wall, highlighting the central role of the endothelium in vascular biology.

Automated summary

Despite advances in modern medicine, atherosclerosis remains a significant medical and social problem leading to cardiovascular diseases with high disability and mortality rates. The development of atherosclerosis is linked to lipid accumulation in arterial walls and disrupted inflammation regulation mechanisms, with fatty acids playing a key role in inflammation processes. Endothelial cells are crucial in vascular biology, demonstrating connections between lipid metabolism, innate immunity, hemodynamics, and other vascular cell functions.