Journal
SIGNAL TRANSDUCTION AND TARGETED THERAPY
Volume 7, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41392-021-00868-x
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Funding
- National Natural Science Foundation of China [82073750, U20A20409]
- Key research and development project of Zhejiang province [2018C03022]
- Fundamental Research Funds for the Central Universities [2020QNA7005]
- Zhejiang Province Qianjiang Talent Plan
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This review article introduces the potential of monoclonal antibodies as targeted anticancer agents and their applications in cancer therapy. It also discusses various types of antibodies, clinical study advances, and the rationale and mechanisms of different antibody formats. Well-designed novel antibodies are paving the way for successful treatments of various cancers in the clinic.
Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells. The successful application of IgG monoclonal antibodies has inspired the development of various types of therapeutic antibodies, such as antibody fragments, bispecific antibodies, and antibody derivatives (e.g., antibody-drug conjugates and immunocytokines). The miniaturization and multifunctionalization of antibodies are flexible and viable strategies for diagnosing or treating malignant tumors in a complex tumor environment. In this review, we summarize antibodies of various molecular types, antibody applications in cancer therapy, and details of clinical study advances. We also discuss the rationale and mechanism of action of various antibody formats, including antibody-drug conjugates, antibody-oligonucleotide conjugates, bispecific/multispecific antibodies, immunocytokines, antibody fragments, and scaffold proteins. With advances in modern biotechnology, well-designed novel antibodies are finally paving the way for successful treatments of various cancers, including precise tumor immunotherapy, in the clinic.
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