Journal
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/jcdd9020055
Keywords
cardiovascular; risk prediction; pregnancy; gestational diabetes; hypertensive disorders of pregnancy; preeclampsia
Categories
Funding
- National Heart Foundation Vanguard Grant
- National Heart Foundation Future Fellowship
- National Health and Medical Research Council (NHMRC)
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Cardiovascular disease is a leading cause of mortality and morbidity in women globally. Pregnancy-related cardiometabolic conditions increase the risk of future cardiovascular disease. Pregnancy provides an opportunity to detect and manage risk factors through risk prediction models.
Cardiovascular disease, especially coronary heart disease and cerebrovascular disease, is a leading cause of mortality and morbidity in women globally. The development of cardiometabolic conditions in pregnancy, such as gestational diabetes mellitus and hypertensive disorders of pregnancy, portend an increased risk of future cardiovascular disease in women. Pregnancy therefore represents a unique opportunity to detect and manage risk factors, prior to the development of cardiovascular sequelae. Risk prediction models for gestational diabetes mellitus and hypertensive disorders of pregnancy can help identify at-risk women in early pregnancy, allowing timely intervention to mitigate both short- and long-term adverse outcomes. In this narrative review, we outline the shared pathophysiological pathways for gestational diabetes mellitus and hypertensive disorders of pregnancy, summarise contemporary risk prediction models and candidate predictors for these conditions, and discuss the utility of these models in clinical application.
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