Journal
VETERINARY SCIENCES
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/vetsci9020084
Keywords
cats; chronic kidney disease; amino acid; tryptophan
Categories
Funding
- Buttons Fund for Feline Kidney Disease Research at the Ohio State University, College of Veterinary Medicine
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This study aimed to compare the serum and fecal amino acid concentrations between cats with chronic kidney disease (CKD) and healthy cats. The results showed that cats with CKD had lower concentrations of certain amino acids and higher concentrations of others in their serum, indicating significant differences compared to healthy cats.
The purpose of the study was to quantify serum and fecal amino acids (AA) in cats with chronic kidney disease (CKD) and compare to healthy cats. Thirty-five cats with International Renal Interest Society Stage 1-4 CKD and 16 healthy mature adult and senior client-owned cats were included in this prospective cross-sectional study. Sera were analyzed for 25 AA concentrations using an ion exchange chromatography AA analyzer with post column ninhydrin derivatization. Voided fecal samples were analyzed for 22 AA concentrations using liquid chromatography with tandem mass spectrometry. CKD cats had lower serum concentrations of phenylalanine (mean difference +/- standard error of the mean: 12.7 +/- 4.3 mu M; p = 0.03), threonine (29.6 +/- 9.2 mu M; p = 0.03), tryptophan (18.4 +/- 5.4 mu M; p = 0.005), serine (29.8 +/- 12.6 mu M; p = 0.03), and tyrosine (11.6 +/- 3.8 mu M; p = 0.01) and higher serum concentrations of aspartic acid (4.7 +/- 2.0 mu M; p = 0.01), beta-alanine (3.4 +/- 1.2 mu M; p = 0.01), citrulline (5.7 +/- 1.6 mu M; p = 0.01), and taurine (109.9 +/- 29.6 mu M; p = 0.01) when compared to healthy cats. Fecal AA concentrations did not differ between healthy cats and CKD cats. 3-Methylhistidine-to-creatinine did not differ between healthy cats with and without muscle loss. Cats with CKD IRIS Stages 1-4 have a deranged serum amino acid profile compared to healthy cats.
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