Journal
NATURE MICROBIOLOGY
Volume 1, Issue 5, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMICROBIOL.2016.23
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Funding
- National Natural Science Foundation of China [81301412, 81422028, 81571975, 61472205]
- Chinese Ministry of Science and Technology (MOST) [2013CB911500]
- Excellent Young Scientist Foundation of Beijing [2013D009004000002]
- Grand Challenges Explorations of the Bill & Melinda Gates Foundation [OPP1021992]
- National Institute of Health of the United States [AI103807, AI099625]
- Academy of Medical Sciences
- Newton Fund
- Academy of Medical Sciences (AMS) [AMS-NAF1-Cheng] Funding Source: researchfish
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The long-term evolutionary interaction between the host immune system and symbiotic bacteria determines their cooperative rather than antagonistic relationship. It is known that commensal bacteria have evolved a number of mechanisms to manipulate the mammalian host immune system and maintain homeostasis. However, the strategies employed by the microbiome to overcome host immune responses in invertebrates still remain to be understood. Here, we report that the gut microbiome in mosquitoes utilizes C-type lectins (mosGCTLs) to evade the bactericidal capacity of antimicrobial peptides (AMPs). Aedes aegypti mosGCTLs facilitate colonization by multiple bacterial strains. Furthermore, maintenance of the gut microbial flora relies on the expression of mosGCTLs in A. aegypti. Silencing the orthologues of mosGCTL in another major mosquito vector (Culex pipiens pallens) also impairs the survival of gut commensal bacteria. The gut microbiome stimulates the expression of mosGCTLs, which coat the bacterial surface and counteract AMP activity. Our study describes a mechanism by which the insect symbiotic microbiome offsets gut immunity to achieve homeostasis.
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