Journal
RSC ADVANCES
Volume 12, Issue 11, Pages 6762-6771Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra00389a
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- Department of Science and Technology (DST), New Delhi
- CSIR, India
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This study reports the synthesis of dihydroisoquinolinone-4-methylboronic esters from N-allylcarboxamides and B-2(Pin)(2)via a domino Heck/borylation approach. A quinoxaline-based NHC-palladacycle [Pd(C boolean AND C:)PPh3Cl], which has been structurally characterized, is used as a catalyst. The scope of the substrate with a wide range of substituents is explored. In addition to the synthesis of the title compounds, a few examples of methylboronic esters of indoline and benzofuran motifs have also been prepared using the same protocol.
Synthesis of dihydroisoquinolinone-4-methylboronic esters from N-allylcarboxamides and B-2(Pin)(2)via domino Heck/borylation approach is reported. A quinoxaline-based NHC-palladacycle [Pd(C boolean AND C:)PPh3Cl], which has been structurally characterized, is used as a catalyst. The scope of the substrate with a wide range of substituents is explored. In addition to the synthesis of title compounds, a few examples of methylboronic esters of indoline and benzofuran motifs have also been prepared using the same protocol.
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