Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 10, Issue 13, Pages 2077-2096Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb02683f
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Funding
- National Natural Science Foundation of China [51973243, 52173150]
- International Cooperation and Exchange of the National Natural Science Foundation of China [51820105004]
- Science and Technology Planning Project of Shenzhen [JCYJ20190807155801657]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029]
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This review summarizes the recent advances in stimuli-responsive supramolecular assemblies based on the host-guest chemistry of CDs. By integrating the host-guest chemistry of CDs with stimuli-responsive functions, various biomedical applications can be achieved in a spatiotemporally controlled manner.
Cyclodextrins (CDs) are widely employed in biomedical applications because of their unique structures. Various biomedical applications can be achieved in a spatiotemporally controlled manner by integrating the host-guest chemistry of CDs with stimuli-responsive functions. In this review, we summarize the recent advances in stimuli-responsive supramolecular assemblies based on the host-guest chemistry of CDs. The stimuli considered in this review include endogenous (pH, redox, and enzymes) and exogenous stimuli (light, temperature, and magnetic field). We mainly discuss the mechanisms of the stimuli-responsive ability and present typical designs of the corresponding supramolecular assemblies for drug delivery and other potential biomedical applications. The limitations and perspectives of CD-based stimuli-responsive supramolecular assemblies are discussed to further promote the translation of laboratory products into clinical applications.
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