Three-component assembly of stabilized fluorescent isoindoles

The tandem addition of an amine and a thiol to an aromatic dialdehyde engages a selective three-component assembly of a fluorescent isoindole. While an attractive approach for diversity-based fluorophore discovery, isoindoles are typically unstable and present considerable challenges for their practical utility. We found that introduction of electron-withdrawing substituents into the dialdehyde component affords stable isoindole products in one step with acceptable yields and high purity.

Automated summary

Stable isoindole products can be synthesized in one step with acceptable yields and high purity by introducing electron-withdrawing substituents.