Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 12, Pages 2392-2396Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00177b
Keywords
-
Categories
Ask authors/readers for more resources
The dynamic kinetic resolution of C-N atropisomeric pyridones was achieved via asymmetric phase-transfer catalysis, utilizing a hydrogen bond and pi interaction. The study revealed key non-covalent interactions between the substrate and catalyst.
The dynamic kinetic resolution of C-N atropisomeric pyridones was achieved via asymmetric phase-transfer catalysis, exploiting a rotational barrier-lowering hydrogen bond in the starting materials. X-ray and NMR experiments revealed the presence of a barrier-raising ground state CHMIDLINE HORIZONTAL ELLIPSIS pi interaction in the product, supported by DFT calculations. A co-crystal of the quinidine-derived phase-transfer catalyst and substrate reveals key substrate-catalyst non-covalent interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available