4.2 Article

Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-kappa B signaling pathway

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Summary: Phthalates, widely used in manufacturing industries beyond plastics, have been shown to have harmful effects on organism health, including reproductive toxicity, cardiotoxicity, hepatotoxicity, nephrotoxicity, teratogenicity, and tumor development. Experimental studies have indicated the involvement of various signaling pathways such as Nrf2, NF-κB, and PI3K/AKT in phthalate-induced toxicity, which can alter cell hemostasis and lead to oxidative stress, inflammation, apoptosis, and cancer. Research focusing on these molecular targets may help reduce environmental chemicals-induced toxicity, especially the toxic effects of phthalates.

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