Journal
HLA
Volume 87, Issue 2, Pages 69-78Publisher
WILEY
DOI: 10.1111/tan.12737
Keywords
immune system; pregnancy; recurrent miscarriage; regulatory T cell; tolerance
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Couples of whom the woman has had a miscarriage have two major concerns: the cause and possible risk of recurrence. Unfortunately, a significant proportion of cases of recurrent miscarriage (RM) remain unexplained despite detailed investigation. Because data suggest that regulatory T cells (Treg) are involved in the maternal acceptance of the allogeneic foetus, RM could possibly be explained by a disturbance of the Treg network. The possible role of Tregs in RM is described in this review, as well as their potential application in diagnostics and therapeutic intervention trials.
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