Asymmetric oxidative Mannich reactions promoted by photocatalysis and electrochemistry

The asymmetric Mannich reaction is an essential method in contemporary organic chemistry. As a representative of clean and green synthesis methods, photochemical and electrochemical oxidation strategies have re-emerged in recent years, providing new ideas for asymmetric Mannich reactions. Numerous chiral beta-amino carbonyl compounds have been accessed in satisfactory yields with excellent enantioselectivity via such novel asymmetric oxidative Mannich reactions. This minireview highlights plentiful advances in asymmetric oxidative Mannich reactions that rely on photoredox or anodic-oxidation and covers the literature from 2014 to date. Furthermore, the future development of this field is envisaged.

Automated summary

This minireview highlights the significant advances in asymmetric oxidative Mannich reactions using photoredox or anodic-oxidation strategies. It discusses the synthesis of chiral beta-amino carbonyl compounds and provides insights into the future development of this field.