4.6 Article

Intermittent Hypoxia Rewires the Liver Transcriptome and Fires up Fatty Acids Usage for Mitochondrial Respiration

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Obstructive sleep apnea, chronic obstructive pulmonary disease and NAFLD: an individual participant data meta-analysis

Ingrid Jullian-Desayes et al.

Summary: This study investigated the association between liver damage and the severity of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) using individual participant data meta-analysis. The results confirmed a strong association between OSA severity and liver steatosis, with the relationship between OSA and fibrosis mainly attributed to BMI as shown by causal mediation analysis.

SLEEP MEDICINE (2021)

Article Gastroenterology & Hepatology

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

Antje Mohs et al.

Summary: In chronic liver diseases, NRF2 activation may protect the liver by ameliorating fibrosis and preventing the progression of hepatocellular carcinoma.

JOURNAL OF HEPATOLOGY (2021)

Review Biochemistry & Molecular Biology

Generation of Reactive Oxygen Species by Mitochondria

Pablo Hernansanz-Agustin et al.

Summary: The paper comprehensively reviews the production of ROS at a mitochondrial level, discusses recent advances in signaling and disease, and the role of supercomplexes in these mechanisms.

ANTIOXIDANTS (2021)

Review Medicine, General & Internal

Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

Anna Pia Delli Bovi et al.

Summary: This article discusses the interplay between oxidative stress and other pathogenic factors in non-alcoholic fatty liver disease (NAFLD), emphasizing the importance of reactive oxygen species (ROS) in NAFLD progression. It also points out the effectiveness of healthy diet and physical activity in NAFLD treatment, but lack of compliance, and the potential of precision medicine in selecting the best treatment for specific patients.

FRONTIERS IN MEDICINE (2021)

Article Biochemistry & Molecular Biology

Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease

Omar A. Mesarwi et al.

Summary: In a mouse model of NAFLD, obstructive sleep apnea exacerbates hepatic steatosis and fibrosis, with HIF-1 signaling worsening metabolic characteristics and accelerating NAFLD progression. Hepatic inflammatory stress may play a role in mediating these effects.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Rohit Loomba et al.

Summary: NAFLD and NASH are leading chronic liver diseases worldwide, causing progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. These diseases are associated with hepatic glucose and lipid metabolism, and are influenced by genetic, epigenetic, and environmental factors.
Review Medicine, General & Internal

Non-alcoholic fatty liver disease

Elizabeth E. Powell et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.

LANCET (2021)

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach

Giovanni Targher et al.

Summary: NAFLD is not only a global public health issue but also proven to be a systemic disease, closely related to various extrahepatic complications. Addressing NAFLD requires establishing a multidisciplinary working group and framework to achieve comprehensive, person-centered care and management.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Cell Biology

Intermittent hypoxia preconditioning protects WRL68 cells against oxidative injury: Involvement of the PINK1/Parkin-mediated mitophagy regulated by nuclear respiratory factor 1

Yapeng Lu et al.

Summary: Intermittent hypoxia (IH) preconditioning protects hepatic cells against oxidative injury by up-regulating NRF-1, PINK1, Parkin, and LC3 II, promoting the initiation of PINK1/Parkin-mediated mitophagy. NRF-1 plays a crucial role in regulating the protective effect of IH preconditioning against oxidative cellular injury.

MITOCHONDRION (2021)

Review Gastroenterology & Hepatology

NRF-2 and nonalcoholic fatty liver disease

Arturo Solano-Urrusquieta et al.

ANNALS OF HEPATOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Cooperation Between Hypoxia-Inducible Factor 1 a and Activating Transcription Factor 4 in Sleep Apnea-Mediated Myocardial Injury

Sophie Moulin et al.

CANADIAN JOURNAL OF CARDIOLOGY (2020)

Article Medicine, Research & Experimental

Cyclophilin D-dependent oligodendrocyte mitochondria ion leak contributes to neonatal white matter injury

Zoya Niatsetskaya et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Biochemistry & Molecular Biology

Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects

Marina Galicia-Moreno et al.

ANTIOXIDANTS (2020)

Article Respiratory System

Adipose tissue as a key player in obstructive sleep apnoea

Silke Ryan et al.

EUROPEAN RESPIRATORY REVIEW (2019)

Article Critical Care Medicine

Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis

Adam V. Benjafield et al.

LANCET RESPIRATORY MEDICINE (2019)

Article Multidisciplinary Sciences

Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake

Jonathan Gaucher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Critical Care Medicine

Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease

Omar A. Mesarwi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease - A global public health perspective

Zobair M. Younossi

JOURNAL OF HEPATOLOGY (2019)

Review Pharmacology & Pharmacy

The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

Dongwei Xu et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Endocrinology & Metabolism

Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep

Swati Chopra et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Editorial Material Gastroenterology & Hepatology

Nocturnal hypoxia in obese-related obstructive sleep apnea as a putative trigger of oxidative stress in pediatric NAFLD progression

Maurizio Parola et al.

JOURNAL OF HEPATOLOGY (2016)

Article Endocrinology & Metabolism

Nonalcoholic fatty liver disease and obstructive sleep apnea

Judith Aron-Wisnewsky et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Article Medicine, General & Internal

Obstructive sleep apnoea syndrome

Patrick Levy et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Review Biochemistry & Molecular Biology

Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

Sara Baldelli et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Article Biophysics

Tissue Oxygenation and Mitochondrial Respiration under Different Modes of Intermittent Hypoxia

Tatiana V. Serebrovskaya et al.

HIGH ALTITUDE MEDICINE & BIOLOGY (2013)

Review Biochemistry & Molecular Biology

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Emilia Kansanen et al.

REDOX BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Bromodomain-dependent stage-specific male genome programming by Brdt

Jonathan Gaucher et al.

EMBO JOURNAL (2012)

Article Gastroenterology & Hepatology

Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese

Judith Aron-Wisnewsky et al.

JOURNAL OF HEPATOLOGY (2012)

Article Gastroenterology & Hepatology

Effects of a high-fat diet on energy metabolism and ROS production in rat liver

Guillaume Vial et al.

JOURNAL OF HEPATOLOGY (2011)