4.5 Review

Predicting response to neoadjuvant chemoradiotherapy in rectal cancer: from biomarkers to tumor models

Related references

Note: Only part of the references are listed.
Article Oncology

T-cell complexity and density are associated with sensitivity to neoadjuvant chemoradiotherapy in patients with rectal cancer

Takashi Akiyoshi et al.

Summary: This study found that patients with increased pre-treatment CD8(+)TIL density and high TCR diversity index had better responses to chemoradiotherapy in rectal cancer, serving as predictive factors for good response to CRT.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

Impact of KRAS status on tumor response and survival after neoadjuvant treatment of locally advanced rectal cancer

Peige Zhou et al.

Summary: In locally advanced rectal cancer patients, mKRAS was not associated with lower pCR rates or NAR scores, but it was independently associated with worse survival.

JOURNAL OF SURGICAL ONCOLOGY (2021)

Review Oncology

Tumour budding in solid cancers

Alessandro Lugli et al.

Summary: Tumour budding serves as an emerging prognostic biomarker in colorectal cancer and other solid cancers, with its predictive accuracy being widely supported by evidence. The standardized scoring system agreed upon at the International Tumour Budding Consensus Conference allows for an independent prediction of pathological features and unfavorable survival outcomes in patients.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study

Yuxi Yi et al.

Summary: The gut microbiome undergoes significant changes during nCRT, with microbes related to butyrate production being overrepresented in responders and certain microbes being overrepresented in nonresponders. A prediction classifier for nCRT response was established, showing high predictive accuracy in the training cohort.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Renu R. Bahadoer et al.

Summary: The RAPIDO trial aimed to reduce systemic relapses in locally advanced rectal cancer through short-course radiotherapy, chemotherapy, and delayed surgery. Results showed a decreased probability of disease-related treatment failure in the experimental group compared to standard care, with diarrhea being the most common adverse event and neurological toxicity being prominent in the standard care group during adjuvant chemotherapy.

LANCET ONCOLOGY (2021)

Review Oncology

Radiotherapy and the gut microbiome: facts and fiction

Jing Liu et al.

Summary: The gut microbiome has a bidirectional relationship with radiotherapy, potentially influencing treatment efficacy by modulating the tumor microenvironment. Personalized approaches such as probiotics, prebiotics, or fecal microbial transplantation may optimize the gut microbiome response to treatment. Further research is needed to explore the mechanisms of radiation on the microbiome and the application of multi-omic methods in investigating functional changes.

RADIATION ONCOLOGY (2021)

Article Oncology

Clinical predictors of pathological good response in locally advanced rectal cancer

Kongfeng Shao et al.

Summary: The study identified clinical predictors of pathological good response (PGR) in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT). Factors such as the distance from the inferior margin of the tumor to the anal verge, pretreatment CEA level, and the interval from the end of radiation to surgery were significant predictors of PGR. Further prospective studies are needed for validation of these results.

RADIATION ONCOLOGY (2021)

Article Oncology

A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer

Klara Hammarstrom et al.

Summary: In rectal cancer patients, tumor size or stage are independent predictors of excellent response to treatment, with small/early-stage tumors more likely to achieve complete remission. Elevated levels of the tumor marker carcinoembryonic antigen (CEA) decrease the chance of response. Radiotherapy or chemoradiotherapy are commonly used in rectal cancer treatment, occasionally resulting in complete tumor remission.

CANCERS (2021)

Review Oncology

The role of the gut microbiome on radiation therapy efficacy and gastrointestinal complications: A systematic review

Marion Tonneau et al.

Summary: Radiation therapy is a crucial component in oncology, but its efficacy varies among patients due to multiple tumor mechanisms. Recent studies show the gut microbiome plays a key role in modulating immune response and treatment outcomes. Despite advancements in radiotherapy techniques, acute adverse events still occur, highlighting the need for further research on improving strategies.

RADIOTHERAPY AND ONCOLOGY (2021)

Review Oncology

Emerging Trends for Radio-Immunotherapy in Rectal Cancer

Claudia Corro et al.

Summary: Despite obstacles in the treatment of rectal cancer patients, recent evidence suggests that radiotherapy combined with immune checkpoint inhibition could be a promising approach. However, the biological and clinical impact of this combination remains unclear, and further studies are needed to optimize its effectiveness. The heterogeneity of rectal cancer at the genetic and molecular levels, as well as the importance of tumor immune contexture, highlight the complexity of developing personalized treatment strategies for this disease.

CANCERS (2021)

Article Oncology

A Patient-Derived Organoid-Based Radiosensitivity Model for the Prediction of Radiation Responses in Patients with Rectal Cancer

Misun Park et al.

Summary: Patient-derived tumor organoids closely resemble original patient tumors, and a machine learning algorithm using clinical and experimental radioresponse data has shown excellent performance in constructing a prediction model.

CANCERS (2021)

Article Oncology

Pathological Predictors of Response to Neoadjuvant Treatment in Rectal Carcinoma

Mona Malekzadeh Moghani et al.

Summary: Tissue factors are crucial in predicting the response to neoadjuvant treatment for rectal cancer, with pathological stage showing the highest correlation with treatment response. CD8 lymphocyte infiltration, primary perineural invasion, and lymphovascular invasion also significantly relate to treatment response.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

Editorial Material Cell & Tissue Engineering

Organoids as Oracles for Precision Medicine in Rectal Cancer

Kevin S. Kolahi et al.

CELL STEM CELL (2020)

Article Oncology

Modeling rectal cancer to advance neoadjuvant precision therapy

Harinarayanan Janakiraman et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Review Gastroenterology & Hepatology

Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers

Amy M. Buckley et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Oncology

Gut Microbiome Composition Is Associated with a Pathologic Response After Preoperative Chemoradiation in Patients with Rectal Cancer

Bum-Sup Jang et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Article Oncology

Preliminary results of the organ preservation of rectal adenocarcinoma (OPRA) trial.

Julio Garcia-Aguilar et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Health Care Sciences & Services

Mucinous and Non-Mucinous Rectal Adenocarcinoma - Differences in Treatment Response to Preoperative Radiotherapy

Karolina Vernmark et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

Review Oncology

Circulating tumor DNA and liquid biopsy in oncology

David W. Cescon et al.

NATURE CANCER (2020)

Article Oncology

Checkpoints and beyond - Immunotherapy in colorectal cancer

Tobias Gutting et al.

SEMINARS IN CANCER BIOLOGY (2019)

Review Oncology

Modulating the microbiome to improve therapeutic response in cancer

Jennifer L. McQuade et al.

LANCET ONCOLOGY (2019)

Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

A rectal cancer organoid platform to study individual responses to chemoradiation

Karuna Ganesh et al.

NATURE MEDICINE (2019)

Review Oncology

The clinical role of the TME in solid cancer

Nicolas A. Giraldo et al.

BRITISH JOURNAL OF CANCER (2019)

Article Biotechnology & Applied Microbiology

miR-145 Antagonizes SNAI1-Mediated Sternness and Radiation Resistance in Colorectal Cancer

Yun Zhu et al.

MOLECULAR THERAPY (2018)

Article Oncology

Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review)

Cory Pettit et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Review Gastroenterology & Hepatology

Gut microbiota modulation of chemotherapy efficacy and toxicity

James L. Alexander et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Oncology

Perineural Invasion Predicts for Distant Metastasis in Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation and Surgery

Priyanka Chablani et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2017)

Article Oncology

XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer

Isabel Ferreiro-Neira et al.

CLINICAL CANCER RESEARCH (2016)

Article Gastroenterology & Hepatology

Rectal cancer: Neoadjuvant chemoradiotherapy

Claus Roedel et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2016)

Article Cell Biology

Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer

Teresa Gomez del Pulgar et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)

Review Medicine, General & Internal

The Human Intestinal Microbiome in Health and Disease

Susan V. Lynch et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Biochemistry & Molecular Biology

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

Article Gastroenterology & Hepatology

MicroRNA-21 predicts response to preoperative chemoradiotherapy in locally advanced rectal cancer

Cristina Carames et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2015)

Article Oncology

Epigenetic Regulation of KLHL34 Predictive of Pathologic Response to Preoperative Chemoradiation Therapy in Rectal Cancer Patients

Ye J. Ha et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2015)

Article Gastroenterology & Hepatology

Normalization of CEA Levels Post-Neoadjuvant Therapy is a Strong Predictor of Pathologic Complete Response in Rectal Cancer

Ariella Kleiman et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2015)

Article Surgery

Predictive markers of response to neoadjuvant therapy in rectal cancer

Luis Joaquin Carcia-Florez et al.

JOURNAL OF SURGICAL RESEARCH (2015)

Article Pathology

Perineural Invasion Is a Strong Prognostic Factor in Colorectal Cancer

Nikki Knijn et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2015)

Review Immunology

Emerging cytokine networks in colorectal cancer

Nathan R. West et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Oncology

Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer

Maria-Gabriela Anitei et al.

CLINICAL CANCER RESEARCH (2014)

Article Gastroenterology & Hepatology

Clinical tumour size and nodal status predict pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer

Mikaela L. Garland et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2014)

Article Multidisciplinary Sciences

Proteogenomic characterization of human colon and rectal cancer

Bing Zhang et al.

NATURE (2014)

Article Gastroenterology & Hepatology

Clinical Prediction of Pathological Complete Response After Preoperative Chemoradiotherapy for Rectal Cancer

Jung Wook Huh et al.

DISEASES OF THE COLON & RECTUM (2013)

Article Gastroenterology & Hepatology

CEA - A Predictor for Pathologic Complete Response After Neoadjuvant Therapy for Rectal Cancer

Ulrik Wallin et al.

DISEASES OF THE COLON & RECTUM (2013)

Article Cell Biology

Gene Methylation in Rectal Cancer: Predictive Marker of Response to Chemoradiotherapy?

Chiara Molinari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

Article Multidisciplinary Sciences

Comparative Analysis of Radiosensitizers for K-RAS Mutant Rectal Cancers

Laura B. Kleiman et al.

PLOS ONE (2013)

Article Oncology

Clinical Outcome of the ACCORD 12/0405 PRODIGE 2 Randomized Trial in Rectal Cancer

Jean-Pierre Gerard et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of human colon and rectal cancer

Donna M. Muzny et al.

NATURE (2012)

Review Oncology

Patient-derived tumour xenografts as models for oncology drug development

John J. Tentler et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

Article Gastroenterology & Hepatology

High survivin expression as a predictor of poor response to preoperative chemoradiotherapy in locally advanced rectal cancer

Kyubo Kim et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2011)

Article Oncology

PREDICTIVE FACTORS OF TUMOR RESPONSE AFTER NEOADJUVANT CHEMORADIATION FOR LOCALLY ADVANCED RECTAL CANCER

Laurence Moureau-Zabotto et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)

Article Oncology

Wait-and-See Policy for Clinical Complete Responders After Chemoradiation for Rectal Cancer

Monique Maas et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Review Oncology

The current landscape of locally advanced rectal cancer

Mebea Aklilu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Article Oncology

PREDICTION OF RESPONSE TO PREOPERATIVE CHEMORADIOTHERAPY IN RECTAL CANCER BY MULTIPLEX KINASE ACTIVITY PROFILING

Sigurd Folkvord et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)

Article Medicine, General & Internal

Colorectal cancer

David Cunningham et al.

LANCET (2010)

Article Oncology

Molecular responses of rectal cancer to preoperative chemoradiation

Annelies Debucquoy et al.

RADIOTHERAPY AND ONCOLOGY (2006)

Review Immunology

Regulatory T cells, tumour immunity and immunotherapy

WP Zou

NATURE REVIEWS IMMUNOLOGY (2006)

Article Oncology

Cox-2 overexpression in pretreatment biopsies predicts response of rectal cancers to neoadjuvant radiochemotherapy

FM Smith et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

Article Oncology

Opinion - CpG island methylator phenotype in cancer

JP Issa

NATURE REVIEWS CANCER (2004)

Article Medicine, General & Internal

Preoperative versus postoperative chemoradiotherapy for rectal cancer

R Sauer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)