Journal
FEMS MICROBIOLOGY REVIEWS
Volume 46, Issue 2, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuab053
Keywords
bacteria; type IV pili; nanomachines; dynamics; bacterial appendages; bacterial behaviors
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Funding
- Canada 150 Research Chair in Bacterial Cell Biology
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Quebec-Nature et Technologies postdoctoral fellowships
- Damon Runyon Cancer Research Foundation [DRG-2385-20]
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This review discusses recent progress in understanding the function, regulation, and mechanisms of T4P dynamics.
Dynamic and widely distributed appendages called type IV pili are essential to diverse microbial lifestyles. Bacteria and archaea rely on appendages called type IV pili (T4P) to participate in diverse behaviors including surface sensing, biofilm formation, virulence, protein secretion and motility across surfaces. T4P are broadly distributed fibers that dynamically extend and retract, and this dynamic activity is essential for their function in broad processes. Despite the essentiality of dynamics in T4P function, little is known about the role of these dynamics and molecular mechanisms controlling them. Recent advances in microscopy have yielded insight into the role of T4P dynamics in their diverse functions and recent structural work has expanded what is known about the inner workings of the T4P motor. This review discusses recent progress in understanding the function, regulation, and mechanisms of T4P dynamics.
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