Journal
SIGNAL TRANSDUCTION AND TARGETED THERAPY
Volume 7, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41392-022-00922-2
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Funding
- Natural Science Foundation of China [81773293, 81873640, 81970569, 82000756]
- Key Project of Science and Technology Program of Hunan Provincial Science and Technology Department [2015GK3117, 2017WK2063]
- Guangxi Jialouyuan Medical Inc.
- Solgro
- UT Arlington
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This review summarizes the mechanisms, diagnosis, and treatment of colorectal liver metastasis (CRLM), with a special focus on the tumor microenvironment and the potential of newer targeted therapies to improve patient prognosis.
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
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