Journal
PHYTOCHEMISTRY
Volume 197, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2024.113108
Keywords
Artemisia macrocephala; Artemisia griffithiana; Asteraceae; Guaianolides; Macrocephalolides A-H; X-ray diffraction; ECD calculation
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Funding
- National Natural Science Foundation of China [U1703235]
- West Light Foundation of the Chi-nese Academy of Science [Y82SA214]
- key Science and Technology Special Projects of Xinjiang-Uyghur Autonomous Re-gion [2016A03005-3]
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Eight undescribed guaianolides and two known analogues were isolated from Artemisia macrocephala in Xinjiang, China. Their structures were determined through extensive spectroscopic analysis and confirmed by experimental and calculated ECD data, as well as X-ray crystallography. The discovery of unique guaianolides with unprecedented structures in natural sesquiterpenes is significant.
Eight undescribed guaianolides (macrocephalolides A-H) and two known analogues (parishin C, artabsinolide E) were isolated from the whole plant of Artemisia macrocephala growing in Xinjiang, China. Their structures were determined on the basis of extensive spectroscopic analysis, with absolute configurations established by comparison of experimental and calculated ECD data, as well as confirmation of single-crystal X-ray diffraction crystallography. Macmcephalolides A-B featured an unusual type of 3-oxa-guaianolide with a cyclopentenone moiety. Macrocephalolides C-E possessed a dihydro-2H-pyran acetal segment, representing an unprecedented 2, 3-secoguaianolide skeleton with 6/7/5 tricyclic ring system in natural sesquiterpenes. The X-ray crystal structures of parishin C and artabsinolide E were reported for the first time.
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