Journal
NEUROPSYCHIATRIC DISEASE AND TREATMENT
Volume 18, Issue -, Pages 555-561Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S348683
Keywords
major depressive disorder; first-episode; ALFF; fALFF; fMRI
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Funding
- Natural Science Foundation of Guangdong Province [2017A030313809]
- Science and Technology Program of Guangzhou [202002030262]
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This study observed the characteristics of low-frequency oscillation (LFO) in first-episode drug-naive patients with major depressive disorder (MDD), and found that abnormal neurological activity in multiple brain regions may be involved in the neurobiological mechanisms of MDD.
Objective: To observe characteristics of the amplitudes of low-frequency oscillation (LFO) in first-episode drug-naive patients with major depressive disorder (MDD). Methods: Amplitudes of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were computed using resting-state functional magnetic resonance imaging (rs-fMRI) data of 39 first-episode drug-naive patients with MDD and 37 healthy controls. Results: ALFF and fALFF in the left cerebellum were significantly higher in patients with MDD compared to control group, while ALFF in the right rolandic operculum was significantly lower (all p < 0.001, AlphaSim correction). Conclusion: Abnormal neurological activity in multiple brain regions in first-episode drug-naive patients with MDD may be involved in the neurobiological mechanisms of MDD and should be considered in future studies.
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