Journal
ARCHIVES OF BONE AND JOINT SURGERY-ABJS
Volume 10, Issue 3, Pages 229-244Publisher
MASHHAD UNIV MED SCIENCES
DOI: 10.22038/ABJS.2022.55549.2766
Keywords
Biochemical; Cartilage; Cartilage regeneration; Scaffold; Tissue engineering
Categories
Funding
- Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Ask authors/readers for more resources
Chondral defects are common causes of pain and disability, and finding ways to regenerate cartilage is crucial. Tissue engineering provides new strategies for the regeneration of functional cartilage tissue through optimized scaffold properties.
Chondral defects are frequent and important causes of pain and disability. Cartilage has limited self-repair and regeneration capacity. The ideal approach for articular cartilage defects is the regeneration of hyaline cartilage with sustainable symptom-free constructs. Tissue engineering provides new strategies for the regeneration of functional cartilage tissue through optimized scaffolds with architectural, mechanical, and biochemical properties similar to the native cartilage tissue. In this review, the basic science of cartilage structure, interactions between proteins, stem cells, as well as biomaterials, scaffold characteristics and fabrication methods, as well as current and potential therapies in regenerative medicine will be discussed mostly from a biochemical point of view. Furthermore, the recent trends in scaffold-based therapies and supplementary factors in cartilage tissue engineering will be considered.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available