Journal
ACS SENSORS
Volume 1, Issue 5, Pages 579-583Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.5b00249
Keywords
activatable fluorescent probe; colon cancer; cyanine dye; gamma-glutamyltranspeptidase
Funding
- National Research Foundation of Korea, Ministry of Science, ICT and Future Planning [NRF-2014R1A2A2A01002430]
- Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI06C0868]
- National Research Foundation of Korea [2014R1A2A2A01002430] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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An activatable fluorescent probe from indocyanine was developed for the detection of tumor-enriched gamma-glutamyltranspeptidase (gamma GT). The probe exhibited a dramatic fluorescence enhancement (F/F-0 = 10) as well as a bathochromic shift (>100 nm) upon the treatment of gamma GT with a low limit of detection of 0.15 unit/L and was further successfully applied as a sensitive probe for gamma GT in the mouse model of colon cancer.
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