4.6 Article

Indocyanine-Based Activatable Fluorescence Turn-On Probe for γ-Glutamyltranspeptidase and Its Application to the Mouse Model of Colon Cancer

Journal

ACS SENSORS
Volume 1, Issue 5, Pages 579-583

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acssensors.5b00249

Keywords

activatable fluorescent probe; colon cancer; cyanine dye; gamma-glutamyltranspeptidase

Funding

  1. National Research Foundation of Korea, Ministry of Science, ICT and Future Planning [NRF-2014R1A2A2A01002430]
  2. Korean Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI06C0868]
  3. National Research Foundation of Korea [2014R1A2A2A01002430] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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An activatable fluorescent probe from indocyanine was developed for the detection of tumor-enriched gamma-glutamyltranspeptidase (gamma GT). The probe exhibited a dramatic fluorescence enhancement (F/F-0 = 10) as well as a bathochromic shift (>100 nm) upon the treatment of gamma GT with a low limit of detection of 0.15 unit/L and was further successfully applied as a sensitive probe for gamma GT in the mouse model of colon cancer.

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