Journal
ACS SENSORS
Volume 1, Issue 3, Pages 258-264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.5b00054
Keywords
localized surface plasmon resonance (LSPR); molecular imprinting; complex protein matrix; polyphenols; biosensing; nanodisks
Funding
- FCT, Fundacao para a Ciencia e Tecnologia [SFRH/BD/72479/2010]
- FSE, Fundo Social Europeu
- RFBR [15-03-99582]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/72479/2010] Funding Source: FCT
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Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.
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