Journal
ACS SENSORS
Volume 1, Issue 12, Pages 1408-1415Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.6b00490
Keywords
fluorescent probe; near-infrared; Rhodol counterpart; Zn(II) ions; photoinduced electron transfer
Funding
- National Institute of General Medical Sciences of the National Institutes of Health [R15GM114751]
- National Science Foundation [1048655]
- Michigan Technological University faculty start-up fund
- Linda J. Horton Laboratory Research Fund
- Research Excellence Fund
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1048655] Funding Source: National Science Foundation
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We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration changes in living cells, and detecting intracellular Zn(II) ions released from intracellular metalloproteins.
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