4.4 Article

PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer

Related references

Note: Only part of the references are listed.
Article Oncology

PTEN loss correlates with T cell exclusion across human cancers

Ziying Lin et al.

Summary: The study highlights the association between PTEN loss and immunotherapy resistance, affecting tumor microenvironment and T cell infiltration, particularly T cell exclusion. PTEN loss leads to an immunosuppressive microenvironment, indicating poor response to immunotherapy and worse survival outcomes.

BMC CANCER (2021)

Article Oncology

Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Anita K. Mehta et al.

Summary: The study reveals that PARP inhibition affects macrophage metabolism and function in BRCA-associated TNBC, and combining PARP inhibition with CSF1R blockade therapy enhances antitumor immunity and prolongs survival. Targeting macrophage-mediated immune suppression can improve the efficacy of PARP inhibitors.

NATURE CANCER (2021)

Article Multidisciplinary Sciences

The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov et al.

NATURE (2020)

Article Multidisciplinary Sciences

Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer

Anniina Farkkila et al.

NATURE COMMUNICATIONS (2020)

Article Oncology

Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer

Adam A. Kraya et al.

CLINICAL CANCER RESEARCH (2019)

Article Oncology

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Alison M. Taylor et al.

CANCER CELL (2018)

Article Biochemistry & Molecular Biology

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Allen W. Zhang et al.

Review Pharmacology & Pharmacy

An Overview of Immune Checkpoint Inhibitors in Gynecologic Cancers

Tara Castellano et al.

CLINICAL THERAPEUTICS (2018)

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

Review Biochemistry & Molecular Biology

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

Samuel F. Bakhoum et al.

Review Immunology

Targeting Resident Memory T Cells for Cancer Immunotherapy

Charlotte Blanc et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Livnat Jerby-Arnon et al.

Article Oncology

Emerging Role and Future Directions of Immunotherapy in Advanced Ovarian Cancer

Thinle Chodon et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2018)

Article Medicine, General & Internal

Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

K. Moore et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer

David Balli et al.

CLINICAL CANCER RESEARCH (2017)

Article Biochemistry & Molecular Biology

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation

Christopher Buccitelli et al.

GENOME RESEARCH (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Michel Enamorado et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

Kara N. Maxwell et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

Weiyi Peng et al.

CANCER DISCOVERY (2016)

Article Biochemical Research Methods

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Zuguang Gu et al.

BIOINFORMATICS (2016)

Article Medicine, General & Internal

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

M. R. Mirza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, Research & Experimental

A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcoma

Kenneth S. Chen et al.

COLD SPRING HARBOR MOLECULAR CASE STUDIES (2016)

Article Biochemistry & Molecular Biology

The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1-/- murine model of ovarian cancer

Jing Huang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

Michael S. Rooney et al.

Article Oncology

Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation

Bella Kaufman et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Multidisciplinary Sciences

Whole-genome characterization of chemoresistant ovarian cancer

Ann-Marie Patch et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Oncology

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer

Panagiotis A. Konstantinopoulos et al.

CANCER DISCOVERY (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Biochemical Research Methods

OptiType: precision HLA typing from next-generation sequencing data

Andras Szolek et al.

BIOINFORMATICS (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Biotechnology & Applied Microbiology

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

El-ad David Amir et al.

NATURE BIOTECHNOLOGY (2013)

Article Biochemistry & Molecular Biology

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

Christopher J. Lord et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

C. Bassi et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Inferring tumour purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara et al.

NATURE COMMUNICATIONS (2013)

Article Cell Biology

Identification of NCF2/p67phox as a novel p53 target gene

Dafne Italiano et al.

CELL CYCLE (2012)

Article Genetics & Heredity

NetMHCcons: a consensus method for the major histocompatibility complex class I predictions

Edita Karosiene et al.

IMMUNOGENETICS (2012)

Review Oncology

Cancer treatment according to BRCA1 and BRCA2 mutations

Kara N. Maxwell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

Article Multidisciplinary Sciences

Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

Junko Matsuzaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

Cheol-Hee Yoon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Oncology

BRCA1 promoter methylation predicts adverse ovarian cancer prognosis

Jing Wang Chiang et al.

GYNECOLOGIC ONCOLOGY (2006)

Article Multidisciplinary Sciences

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

E Sato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Article Medicine, General & Internal

Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

L Zhang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)