Journal
SIGNAL TRANSDUCTION AND TARGETED THERAPY
Volume 7, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41392-022-00932-0
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Funding
- National Key R&D Program of China [2018YFA0107500, 2021YFA1100600]
- National Natural Science Foundation of China [81930085, 32150710523, 31961133024]
- Jiangsu Province International Science and Technology Cooperation Program [BZ2019017]
- State Key Laboratory of Radiation Medicine and Protection, Soochow University [GZN1201804, GZN1201903]
- Ministry of Health (IDI-IRCCS)
- MAECI Italy-China Science and Technology Cooperation [PGR00961]
- National Center for International Research-Cambridge-Su Genomic Research Center [2017B01012]
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Mesenchymal stromal/stem cells (MSCs) possess the potential of multi-lineage differentiation and self-renewal, and their therapeutic effects in treating inflammatory diseases are mainly achieved through the secretion of factors that regulate immune response, tissue remodeling, and cellular homeostasis.
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases.
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