Journal
POLYMER CHEMISTRY
Volume 13, Issue 14, Pages 2057-2064Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2py00258b
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Funding
- Monash University
- Australian Research Council [DP190103309]
- German Academic Exchange Service (DAAD) [57446038]
- Universities Australia [57446038]
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This study presents a novel method for synthesizing semi-conducting polymer nanoparticles (SPN) and demonstrates their potential as versatile theragnostic platforms for drug delivery and near infrared (NIR) imaging.
Although semiconducting polymer nanoparticles (SPN) are emerging as versatile theragnostic platforms for drug delivery and near infrared (NIR)-imaging, their synthesis remains restricted to nanoprecipatation or graft polymers. Here we present a novel method for creating an SPN of the donor-acceptor conjugated polymer p(IDT-NDI) containing indacenodithienothiophene (IDT) and naphthalene diimide (NDI) units. The conjugated polymer is functionalised with a styryl endgroup which is used to introduce a RAFT-agent via a 1,2-radical insertion reaction. This results in a conjugated macroinitiator which can be chain extended using classical RAFT polymerization with methyl acrylate resulting in an amphiphillic triblock copolymer. The amphiphile showed excellent self-assembly with stable particles of 80-110 nm diameter and absorption and emission in the NIR-region. The micelles are taken up efficiently by cells and can deliver a payload proving this method to be a new and powerful tool for the future of SPN in bioimaging.
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