Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 30, Pages 4779-4782Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc00078d
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Funding
- National Natural Science Foundation of China [22076073, 21775063]
- Natural Science Foundation of Shandong Provincial Department of Science and Technology [ZR2021QB206, ZR2017LB019]
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We present a simple aptamer assay for rapid analysis of the carcinogenic fungal metabolite AFB1. By rationally truncating the original anti-AFB1 aptamer, a short aptamer with improved performance was obtained. Different concentrations of AFB1 were detected by measuring the circular dichroism spectra of this short aptamer. The detection limit reached 0.6 nM, which was lower than that of the original aptamer (80 nM).
We describe a simple aptamer assay for the rapid analysis of aflatoxin B1 (AFB1), a potently carcinogenic fungal metabolite. The original anti-AFB1 aptamer was rationally truncated, obtaining a short aptamer that displayed better performance. Different concentrations of AFB1 were detected by measuring the circular dichroism spectra of this short aptamer. The detection limit reached 0.6 nM, which was lower than that of the original aptamer (80 nM).
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