Journal
NANOSCALE
Volume 14, Issue 14, Pages 5488-5500Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nr08158f
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Funding
- Ministerio de Economia y Competitividad de Espana [PID2020-113704RB-I00, PID2020-119242RB-I00]
- Xunta de Galicia (Centro Singular de Investigacion de Galicia) [ED431G 2019/06, IN607A 2018/5, ED431C 2020-06]
- European Union (EU-ERDF Interreg V-A - Spain-Portugal) [0245_IBEROS_1_E, 0712_ACUINANO_1_E, 0624_2IQBIONEURO_6_E, NANOCULTURE 1.102.531]
- Portuguese Foundation for Science and Technology (FCT) [UIDB/04650/2020, UIDB/00686/2020, UID/CTM/50025/2020]
- COMPETE2020 [PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), PTDC/QUI-QOR/29015/2017 (POCI-01-0145-FEDER-029015)]
- FCT [SFRH/BD/144017/2019]
- MAP-Fis Doctoral Programme
- FCT
- FEDER
- PORTUGAL2020
- European Union H2020-MSCA-RISE-2019 PEPSA-MATE project
- Fundação para a Ciência e a Tecnologia [UIDB/00686/2020] Funding Source: FCT
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This study presents a novel design approach to modulate drug release through the co-assembly of nanoparticles, liposomes, and drugs in a gel matrix. This approach enhances gelation kinetics and enables controlled drug release through thermal and magnetic field triggers.
Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs.
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