Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 29, Pages 4561-4587Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc00172a
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Funding
- SERB [EMR/2014/385]
- University of Hyderabad (UoH-IoE)
- University of Hyderabad (UPE-CAS)
- University of Hyderabad (PURSE-FIST)
- DSKPDF, UGC, India
- CSIR India
- UGC India
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Transition-metal catalyzed directing group assisted annulation of inert C-H bonds is a method for constructing complex molecular frameworks from readily accessible substrates. It allows the activation of directed inert C-H bonds and migration of transition metals, leading to the formation of structurally diverse fused pi-extended (hetero)cycles. The coordination preference of the directing group heteroatom determines the chemo- and regio-selectivity of the transformation. This study emphasizes the conceptual development of unsymmetrical multiple annulation of arene C(sp(2))-H bonds with alkynes, which is highly important.
Transition-metal catalyzed directing group (DG) assisted annulation of inert C-H bonds leads to the formation of complex molecular frameworks from readily accessible substrates. Thus, multiple annulation of less functionalized substrates with unsaturated species leads to the construction of structurally diverse fused poly(hetero)cycles. The directed inert C(arene)-H bond activation and the mode of TM-migration in this process could enabled obatining L-type [involves DG heteroatom, o-C(arene)-H bond, and C(arene)-H bond of aryl-motif in alkyne], Y-type [involves two heteroatoms of the DG and o-,o'-C(arene)-H bonds], and B-type [involves o-C(arene)-H bond and m-C(arene)-H bond] pi-extended annulation products. The coordination preference of the DG heteroatom makes the transformation chemo- and regio-selective. This article underlines the conceptual development of unsymmetrical multiple annulation of arene C(sp(2))-H bonds with alkynes, which is exceedingly appealing and highly important.
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