On the Modeling of Transcatheter Therapies for the Aortic and Mitral Valves: A Review

Transcatheter aortic valve replacement (TAVR) has become a milestone for the management of aortic stenosis in a growing number of patients who are unfavorable candidates for surgery. With the new generation of transcatheter heart valves (THV), the feasibility of transcatheter mitral valve replacement (TMVR) for degenerated mitral bioprostheses and failed annuloplasty rings has been demonstrated. In this setting, computational simulations are modernizing the preoperative planning of transcatheter heart valve interventions by predicting the outcome of the bioprosthesis interaction with the human host in a patient-specific fashion. However, computational modeling needs to carry out increasingly challenging levels including the verification and validation to obtain accurate and realistic predictions. This review aims to provide an overall assessment of the recent advances in computational modeling for TAVR and TMVR as well as gaps in the knowledge limiting model credibility and reliability.

Automated summary

Transcatheter aortic valve replacement (TAVR) has become an important milestone for managing aortic stenosis in patients who are not suitable for surgery. Computational simulations have been used to predict the interaction between bioprostheses and patients in a patient-specific manner, improving preoperative planning. This review evaluates the recent advances in computational modeling for TAVR and TMVR.