Samarium(ii) iodide-mediated reactions applied to natural product total synthesis

Natural product synthesis remains a field in which new synthetic methods and reagents are continually being evaluated. Due to the demanding structures and complex functionality of many natural products, only powerful and selective methods and reagents will be highlighted in this proceeding. Since its introduction by Henri Kagan, samarium(ii) iodide (SmI2, Kagan's reagent) has found increasing use in chemical synthesis. Over the years, many reviews have been published on the application of SmI2 in numerous reductive coupling procedures as well as in natural product total synthesis. This review highlights recent advances in SmI2-mediated synthetic strategies, as applied in the total synthesis of natural products since 2004.

Automated summary

Natural product synthesis is a constantly evolving field that evaluates new synthetic methods and reagents to address the complexities of structures and functions. SmI2, a widely-used reagent in chemical synthesis, has been highlighted in this review for its recent advances and strategies used in the total synthesis of natural products since 2004.