Rational construction of a triphenylphosphine-modified tetra-nuclear Cu(i) coordinated cluster for enhanced chemodynamic therapy

Article Chemistry, Multidisciplinary

Alkylgold(III) Complexes Undergo Unprecedented Photo-Induced β-Hydride Elimination and Reduction for Targeted Cancer Therapy

Jia Jiang et al.

Summary: The stable alkylgold(III) complexes can undergo unprecedented photo-induced beta-hydride elimination within tumors, releasing bioactive [Au-III-S] adducts that exhibit efficient tumor-selective uptake and antitumor activities.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Organic

Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4-thiazolidinone and 1,2,4-triazole-3-thione derivatives

Efe Dogukan Dincel et al.

Summary: A series of novel compounds with potential antibacterial and antifungal activities were designed and synthesized, among which compounds 6d, 7c, and 7d showed promising biological activities. Compound 6d exhibited potent antifungal activity, suggesting its potential as a lead structure for future drug development.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems

Yan Long et al.

Summary: A new bioorthogonal activation approach utilizing Pd(II)-triggered transmetallation reactions has been reported to conditionally activate the bio-reactivity of NHC-Au(I)-phenylacetylide complexes. This activation approach shows potential applications in inhibiting cancer cell proliferation and angiogenesis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Medicinal

A novel selective mitochondrial-targeted curcumin analog with remarkable cytotoxicity in glioma cells

Lei Shi et al.

Summary: A mitochondria-targeted compound DMC-TPP was prepared to enhance bioavailability and treatment efficacy, showing higher cytotoxicity and mitochondria accumulation ability in vitro. DMC-TPP triggered mitochondria-dependent apoptosis and efficiently inhibited cellular thioredoxin reductase, leading to delayed tumor progression in a mouse xenograft model of human glioma cancer.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Copper-Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T-Cell Infiltration

Yuxiang Wang et al.

Summary: The use of Cu-based nanoscale coordination polymers in combination with radiation therapy can induce potent ICD, leading to enhanced dendritic cell maturation and promotion of anti-tumor T-cell infiltration, which can potentiate the efficacy of checkpoint blockade immunotherapies against primary and metastatic tumors.

SMALL (2021)

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Article Engineering, Biomedical

Mitochondria Targeted O2 Economizer to Alleviate Tumor Hypoxia for Enhanced Photodynamic Therapy

Ping Yuan et al.

Summary: In this study, a mitochondria targeted O-2 economizer (Mito-OxE) was developed to improve the efficiency of photodynamic therapy by alleviating tumor hypoxia and enhancing the subcellular localization of photosensitizers. The targeted drug delivery system shows promising results in enhancing PDT efficacy against hypoxic tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Construction of a nanotheranostic system Zr-MOF@PPa/AF@PEG for improved photodynamic therapy effects based on the PDT-oxygen consumption and hypoxia sensitive chemotherapeutic drug

Xingchao Wang et al.

Summary: Photodynamic therapy is effective in tumor treatment but is weakened by the hypoxic and acidic tumor microenvironment. A designed nano composite effectively combines PDT and chemotherapy to tackle the hypoxic challenge and shows great potential for tumor imaging.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2021)

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Article Materials Science, Biomaterials

Synergistically enhanced multienzyme catalytic nanoconjugates for efficient cancer therapy

Sheng-Yan Yin et al.

Summary: The study presents a robust cascade biomimetic nanoplatform integrating chemiluminescence-induced photodynamic therapy, Fenton reaction-based chemodynamic therapy, and glucose oxidase-mediated starvation therapy to enhance cancer treatment synergistically. The nanoplatform shows excellent anti-tumor performance in both in vitro and in vivo studies, broadening the pathway to fight against cancer through effective cascade catalysis.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Medicine, Research & Experimental

Mn3+-rich oxide/persistent luminescence nanoparticles achieve light-free generation of singlet oxygen and hydroxyl radicals for responsive imaging and tumor treatment

Dandan Ding et al.

Summary: By decomposing the MnOx shell in the tumor region to produce Mn3+ and oxygen, this study demonstrates enhanced XEPL and MR imaging for accurate diagnosis of deep tumors. Furthermore, the method efficiently inhibits tumor growth by producing singlet oxygen and highly toxic hydroxyl radicals through a self-supplied oxygen effect.

THERANOSTICS (2021)

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Article Materials Science, Biomaterials

A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression

Huiwen Zhang et al.

Summary: The study introduced a dual-catalytic nanoreactor for tumor metastasis suppression through synergistic chemodynamic therapy and starvation therapy, enhancing delivery efficiency and biological safety while effectively suppressing tumor metastasis with minimal side effects.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary