Journal
GELS
Volume 8, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/gels8030146
Keywords
gelatin-based composite hydrogels; cellulose nanocrystals; silanization; mechanical property; microbial transglutaminase
Categories
Funding
- Major projects of tackling key industrial of Shandong's Newtraditional Kinetic Energy Conversion
- Natural Science Foundation of Shandong Province [ZR2020QB183]
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Mechanically enhanced gelatin-based composite hydrogels were developed using functionalized cellulose nanocrystals (CNCs) and microbial transglutaminase (mTG) as a binding agent, resulting in significantly improved mechanical properties and thermo-stability. The biocompatibility of the hydrogels was evaluated and showed no obvious inhibitory effect on cell proliferation, indicating great potential for biomedical applications.
Mechanically enhanced gelatin-based composite hydrogels were developed in the presence of functionalized cellulose nanocrystals (CNCs) employing microbial transglutaminase (mTG) as a binding agent. In this work, the surfaces of CNCs were grafted with (3-Aminopropyl) trimethoxysilane with a NH2 functional group, and the success of CNCs' modification was verified by FTIR spectroscopy and XPS. The higher degree of modification in CNCs resulted in more covalent cross-linking and dispersibility within the gelatin matrix; thus, the as-prepared hydrogels showed significantly improved mechanical properties and thermo-stability, as revealed by dynamic rheological analysis, uniaxial compression tests and SEM. The biocompatibility of the obtained hydrogels was evaluated by the MTT method, and it was found that the grafted CNCs had no obvious inhibitory effect on cell proliferation. Hence, the mechanically enhanced gelatin-based hydrogels might have great potential in biomedical applications.
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