Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 36, Pages 5518-5521Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc01170k
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Funding
- Ministerio de Ciencia e Innovacio'ky Institute of Organic Chemistry [PGC2018-094503-B-C21]
- Cabildo de Tenerife for the Agusti'n de Betancourt programme
- European Social Fund (ESF)
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Dynamic nucleophilic aromatic substitution of tetrazines (S(N)Tz) has been used to build theranostic prodrugs that are activated by hydrogen sulfide, allowing for selective release of drugs and/or fluorescent compounds.
Dynamic nucleophilic aromatic substitution of tetrazines (S(N)Tz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such a way, a dual release of drugs and/or fluorescent compounds can be selectively triggered.
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