Native carboxyl group-assisted C-H acetoxylation of hydrocinnamic and phenylacetic acids

The use of a native directing group to promote C-H activation is highly desirable. Herein, we report a method of native carboxyl-assisted, Pd(ii)-catalyzed ortho-C-H acetoxylation of both hydrocinnamic and phenylacetic acids that can be found in many biologically active molecules as the key moieties. Based on the broad scope and the application potential showcased with drug molecules, it is anticipated that this C-H acetoxylation reaction will find attractive applicability in future synthetic endeavors.

Automated summary

This study presents a method of employing a native directing group for C-H activation, specifically focusing on the ortho-C-H acetoxylation of hydrocinnamic and phenylacetic acids, which are key moieties in many biologically active molecules. The broad scope and potential application of this reaction, as demonstrated with drug molecules, indicate its promising utility in future synthetic endeavors.