Journal
CURRENT ISSUES IN MOLECULAR BIOLOGY
Volume 44, Issue 3, Pages 1247-1256Publisher
MDPI
DOI: 10.3390/cimb44030083
Keywords
multiple sclerosis; NR4A; NURR1; sphingosine-1-phosphate (S1P) receptors; siponimod; fingolimod; CNS resident cells
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Funding
- Novartis
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Fingolimod and siponimod are drugs used for the treatment of multiple sclerosis by activating sphingosine-1-phosphate receptors. BAF312 has pro-myelination and neuro-protective effects on CNS cells, and this effect may be related to the regulation of NR4A genes.
Fingolimod (FTY720) and siponimod (BAF312) are selective agonists for sphingosine-1-phosphate (S1P) receptors approved for the treatment of relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), respectively. BAF312 exerts pro-myelination and neuro-protective functions on CNS resident cells, although the underlying molecular mechanism is not yet fully understood. NR4A2 is an anti-inflammatory gene, belonging to the NR4A family, whose expression is reduced in blood from treatment-naive patients with RRMS, but is restored in patients treated with FTY720 for more than two years. We performed an in vitro study to investigate the potential involvement of the NR4A genes in the protective and restorative effects of BAF312. We showed that BAF312 enhances the expression of NR4A1 and NR4A2 in the N9 microglial cell line, but has no effect in the peripheral blood mononuclear cells and oligodendrocytes. This study suggests a novel molecular mechanism of action for the selective agonists for S1P receptors within the CNS.
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