Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 16, Pages 3348-3358Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00230b
Keywords
-
Categories
Funding
- Council of Scientific and Industrial Research, New Delhi
- University Grants Commission, New Delhi
- SERB, Department of Science and Technology, India [CRG/2019/001664]
Ask authors/readers for more resources
Asymmetric total synthesis of an acetate analogue of the endophytic unstable secondary metabolite bipolamide A has been achieved for the first time adopting a convergent approach. The stereochemistry of the unassigned C-8 center of the naturally occurring unstable bipolamide A has been unambiguously established through our synthesis.
Asymmetric total synthesis of an acetate analogue of the endophytic unstable secondary metabolite bipolamide A has been achieved for the first time adopting a convergent approach. The key feature of this synthesis includes Evans's asymmetric ethylation, Wittig olefination, Takai olefination, stereoselective Grignard addition and intermolecular Heck coupling. This eventually developed a synthetic route of the rarely found branched amine bearing an acyloin moiety. Our synthesis finally established unambiguously the stereochemistry of the unassigned C-8 center of the naturally occurring unstable bipolamide A.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available