Advances in the Characterization of the Mechanism Underlying Bacterial Canker Development and Tomato Plant Resistance

Bacterial canker caused by the Gram-positive actinobacterium Clavibacter michiganensis is one of the most serious bacterial diseases of tomatoes, responsible for 10-100% yield losses worldwide. The pathogen can systemically colonize tomato vascular bundles, leading to wilting, cankers, bird's eye lesions, and plant death. Bactericidal agents are insufficient for managing this disease, because the pathogen can rapidly migrate through the vascular system of plants and induce systemic symptoms. Therefore, the use of resistant cultivars is necessary for controlling this disease. We herein summarize the pathogenicity of C. michiganensis in tomato plants and the molecular basis of bacterial canker pathogenesis. Moreover, advances in the characterization of resistance to this pathogen in tomatoes are introduced, and the status of genetics-based research is described. Finally, we propose potential future research on tomato canker resistance. More specifically, there is a need for a thorough analysis of the host-pathogen interaction, the accelerated identification and annotation of resistance genes and molecular mechanisms, the diversification of resistance resources or exhibiting broad-spectrum disease resistance, and the production of novel and effective agents for control or prevention. This review provides researchers with the relevant information for breeding tomato cultivars resistant to bacterial cankers.

Automated summary

This article summarizes the pathogenicity of Clavibacter michiganensis in tomato plants and the molecular basis of bacterial canker pathogenesis. It introduces advances in the characterization of resistance to this pathogen in tomatoes and describes the current status of genetics-based research. Furthermore, potential future research on tomato canker resistance is proposed, including in-depth analysis of the host-pathogen interaction, accelerated identification and annotation of resistance genes and molecular mechanisms, diversification of resistance resources or exhibiting broad-spectrum disease resistance, and the production of novel and effective agents for control or prevention.