Real-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks

Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal-organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, will potentially enhance the performance in cancer therapy.

Automated summary

This study presents a metal-organic framework (MOF)-based nanotheranostic system that enables real-time drug release monitoring and combined chemo-photothermal therapy. By encapsulating photothermal agents (CuS) and therapeutic drug (DOX), the system achieves effective treatment while allowing drug release behaviors to be monitored in real-time. Moreover, the addition of folic acid-conjugated polyethylene glycol (FA-PEG) antennas enhances the active targeting effect of the system towards cancer cells.