Decatungstate-photocatalyzed direct coupling of inert alkanes and quinoxalin-2(1H)-ones with H2 evolution

A tetrabutylammonium decatungstate (TBADT)-photocatalyzed direct coupling of inert alkanes and quinoxalin-2(1H)-ones with H-2 evolution was developed at room temperature. The present transformation achieved direct C(sp(3))-H/C(sp(2))-H coupling under noble metal-free, acid-free and oxidant-free conditions. With this method, a series of 3-alkylated quinoxalin-2(1H)-ones bearing various functional groups were synthesized in good to excellent yields.

Automated summary

The direct coupling reaction between inert alkanes and quinoxalin-2(1H)-ones was successfully achieved under noble metal-free, acid-free, and oxidant-free conditions, leading to the synthesis of various 3-alkylated quinoxalin-2(1H)-ones with good to excellent yields.