Journal
MOLECULAR PAIN
Volume 18, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/17448069221087034
Keywords
Thalamus; anterior cingulate cortex; mapping; volumetric imaging with synchronized on-the-fly-scan and readout; retrograde projection
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Funding
- Canadian Institute for Health Research (CIHR) [PJT-148648, 419286]
- National Science Foundation of China [32100810]
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The anterior cingulate cortex (ACC) plays important roles in pain perception and emotion, with the thalamocortical pathway being the major sensory input. Adult mice, especially genetically modified mice, provide important mechanisms for cortical plasticity and modulation in the ACC. Research found that cortical neurons in the ACC received direct projections from different sub-nuclei in the thalamus.
The anterior cingulate cortex (ACC) is located in the frontal part of the cingulate cortex, and plays important roles in pain perception and emotion. The thalamocortical pathway is the major sensory input to the ACC. Previous studies have show that several different thalamic nuclei receive projection fibers from spinothalamic tract, that in turn send efferents to the ACC by using neural tracers and optical imaging methods. Most of these studies were performed in monkeys, cats, and rats, few studies were reported systematically in adult mice. Adult mice, especially genetically modified mice, have provided molecular and synaptic mechanisms for cortical plasticity and modulation in the ACC. In the present study, we utilized rabies virus-based retrograde tracing system to map thalamic-anterior cingulate monosynaptic inputs in adult mice. We also combined with a new high-throughput VISoR imaging technique to generate a three-dimensional whole-brain reconstruction, especially the thalamus. We found that cortical neurons in the ACC received direct projections from different sub-nuclei in the thalamus, including the anterior, ventral, medial, lateral, midline, and intralaminar thalamic nuclei. These findings provide key anatomic evidences for the connection between the thalamus and ACC.
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