Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 10, Pages 2680-2684Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00198e
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21871228]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_17R94]
- National Key R&D Program of China [2019YFE0109200]
Ask authors/readers for more resources
An efficient and practical strategy for the nitrogen-centered radical mediated alpha-sulfonimidation of carbonyl compounds has been established. This strategy enables the sulfonimidation of enol esters to alpha-sulfonimide ketones under ambient conditions, and offers a convenient method for reacting with a diverse range of aromatic and aliphatic ketones with multiple structures. Additionally, it allows for stereoselective alpha-sulfonimidation in complex natural products when a bulky leaving group is employed.
An efficient and practical strategy for a nitrogen-centered radical mediated alpha-sulfonimidation of carbonyl compounds is established. The ketone alpha-sulfonimidation was initiated by a benzenesulfonimide radical generated from NFSI under the catalytic reduction of TEMPO that enables the sulfonimidation of enol esters to alpha-sulfonimide ketones under ambient conditions. This strategy conveniently engaged a diverse range of aromatic and aliphatic ketones with multiple structures. We also discovered that the stereoselective alpha-sulfonimidation was easily realized when a bulky leaving group was employed in the complex natural products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available