4.7 Review

Targeting ferroptosis as a vulnerability in cancer

Related references

Note: Only part of the references are listed.
Article Cell Biology

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Hai-Liang Zhang et al.

Summary: Through CRISPR-Cas9 and kinase inhibitor screening, Zhang et al. found that PKC beta II phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.

NATURE CELL BIOLOGY (2022)

Article Biotechnology & Applied Microbiology

Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death

Yang Liu et al.

Summary: The interplay between the signals of MTOR and GPX4 modulates autophagy-dependent ferroptosis in human pancreatic cancer cells, with GPX4 playing an essential role in inhibiting this process. Depletion of GPX4 enhances the anticancer activity of rapamycin and RSL3 in vitro or in vivo. These findings may lead to the development of new antitumor therapy targeting autophagy-dependent cell death.

CANCER GENE THERAPY (2021)

Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

Article Biochemistry & Molecular Biology

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

Xiang Luo et al.

Summary: This study establishes a novel pathway for the phagocytic clearance of ferroptotic cells and identifies key molecules involved in the process. The results demonstrate that SAPE-OOH on the surface of ferroptotic cells acts as an eat-me signal and initiates phagocytosis by macrophages through TLR2 recognition.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biochemistry & Molecular Biology

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

Bo Yan et al.

Summary: Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of polyunsaturated phospholipids on cell membranes, which is carried out by oxidoreductases transferring electrons to oxygen to generate hydrogen peroxide for lipid peroxidation. This process needs to be counteracted by antioxidant systems to prevent cell death.

MOLECULAR CELL (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Oncology

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers et al.

Summary: Metabolic vulnerabilities of CD8(+) T cells and cancer cells were identified through a high-throughput in vitro pharmacologic screening platform, with CD8(+) T cells found to be more sensitive to ferroptosis induction. The screening platform may also be useful for rapid testing of compounds targeting antitumor CD8(+) T-cell function and potential therapeutic targets.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

Article Immunology

Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis

Huabin Zhu et al.

Summary: MDSCs are immune suppressive cells that accumulate in pathological conditions to suppress T cell immune response. ASAH2 is highly expressed in tumor-infiltrating MDSCs and acts as a survival factor, targeting ASAH2 can induce MDSC ferroptosis to suppress MDSC accumulation in cancer immunotherapy.

JOURNAL OF IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Wan-Yang Sun et al.

Summary: By hydrolyzing 15-HpETE-PE, iPLA(2)beta prevents ferroptosis, while its dysfunction increases cellular sensitivity to ferroptosis. Mutations in PLA2G6 gene may be implicated in the pathogenesis of Parkinson's disease.

NATURE CHEMICAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway

Chao-Chieh Lin et al.

Summary: Recurrent breast cancer cells are highly sensitive to ferroptosis and exhibit high expression of DDR2. EMT regulators TWIST and SNAIL induce DDR2 expression, leading to increased sensitivity to ferroptosis, while DDR2 inhibition can effectively reduce clonogenic proliferation in these cells.

ONCOGENE (2021)

Article Cell Biology

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

Xinxin Song et al.

Summary: Glucose determines the sensitivity of human pancreatic ductal carcinoma cells to ferroptosis and PDK4 is identified as the top gene responsible for ferroptosis resistance. Inhibiting PDK4 enhances the anticancer activity of system xc(-) inhibitors in vitro and in suitable preclinical mouse models. These findings suggest metabolic reprogramming as a potential target for overcoming ferroptosis resistance.

CELL REPORTS (2021)

Editorial Material Cell Biology

Cytochrome P450 reductase (POR) as a ferroptosis fuel

Pranavi Koppula et al.

PROTEIN & CELL (2021)

Article Hematology

Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL

Anja Schmitt et al.

Summary: The study demonstrates the broad antitumor effect of dimethyl fumarate (DMF) on both subtypes of DLBCL by inducing ferroptosis, especially in GCB DLBCL. In ABC DLBCL cells, DMF treatment efficiently inhibits the activity of the IKK complex and Janus kinases. Additionally, the combination of BCL-2-specific BH3 mimetic ABT-199 and an inhibitor of ferroptosis suppressor protein 1 synergize with DMF in inducing cell death in DLBCL.

BLOOD (2021)

Article Biochemistry & Molecular Biology

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

Weiwei Cui et al.

Summary: Ferroptosis is primarily induced by peroxidation of long-chain PUFA, but the role of SFA remains unclear. The study identified FAR1 as a key factor in SFA-mediated ferroptosis, involved in the synthesis of alkyl-ether lipids and plasmalogens, revealing a new pathway for ferroptosis.

CELL DEATH AND DIFFERENTIATION (2021)

Article Multidisciplinary Sciences

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao et al.

Summary: The study reveals the mechanism of ferroptosis induced by inhibiting GPX4 in cancer cells, as well as the potential pathways to enhance or inhibit ferroptosis by intervening in relevant metabolic pathways. Therapeutic strategies targeting different levels of GPX4 expression could be a promising new approach for cancer treatment.

NATURE (2021)

Article Biochemistry & Molecular Biology

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

Guang Lei et al.

Summary: The study reveals the critical role of ferroptosis in p53-mediated tumor radiosensitivity, promoting lipid peroxidation and cell death by inhibiting SLC7A11. P53 deficiency leads to radioresistance in cancer cells or tumors, while ferroptosis inducers that inhibit SLC7A11 significantly enhance tumor sensitivity to radiotherapy.

ONCOGENE (2021)

Article Multidisciplinary Sciences

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

Christina M. Bebber et al.

Summary: The loss of TP53 and RB1 in treatment-naive small cell lung cancer (SCLC) indicates a need to inactivate cell death pathways prior to therapy. This study identifies non-neuroendocrine (NE) SCLC as vulnerable to ferroptosis and neuroendocrine (NE) SCLC as susceptible to TRX pathway inhibition, with combining these treatments showing promise in overcoming subtype plasticity in SCLC.

NATURE COMMUNICATIONS (2021)

Article Oncology

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance

Sze Kiat Tan et al.

Summary: The study found that obesity and tumor cells contribute to ccRCC through the expression of chemerin, which plays an indispensable role in ccRCC biology. Inhibition of chemerin can reduce lipid accumulation and inhibit tumor growth, highlighting potential therapeutic strategies for patients with ccRCC. Targeting lipid metabolism via inhibition of a soluble factor like chemerin presents a promising pharmacologic approach.

CANCER DISCOVERY (2021)

Review Cell Biology

Ferroptosis, radiotherapy, and combination therapeutic strategies

Guang Lei et al.

Summary: Ferroptosis, an iron-dependent form of regulated cell death, plays an important role in radiotherapy-induced cell death and tumor suppression, mediating synergy with immunotherapy. This review summarizes the crosstalk between radiotherapy and ferroptosis, and explores combination therapeutic strategies.

PROTEIN & CELL (2021)

Editorial Material Biochemistry & Molecular Biology

Ether phospholipids govern ferroptosis Comment

Hyemin Lee et al.

Summary: Recent studies have highlighted the critical role of ether-linked phospholipids in providing polyunsaturated fatty acid-containing phospholipids in ferroptosis, as well as the context-dependent role of TMEM189-mediated vinyl-ether phospholipid synthesis in ferroptosis.

JOURNAL OF GENETICS AND GENOMICS (2021)

Article Immunology

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis

Yin Yao et al.

Summary: Researchers found that T follicular helper (T-FH) cells are highly sensitive to ferroptosis, and this process is regulated by the activity of the selenoenzyme GPX4. Selenium supplementation can increase GPX4 expression, leading to an increase in T-FH cell numbers and antibody responses.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Daniel M. Kremer et al.

Summary: Cancer metabolism is rewired to support cell survival, with targeting metabolic dependencies following GOT1 inhibition leading to ferroptosis, an iron-dependent form of cell death. The study identifies a biochemical connection between GOT1, iron regulation, and ferroptosis in pancreatic cancer cells.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

Chengxian Xu et al.

Summary: Research shows that Gpx4 plays a crucial role in protecting Treg cells from lipid peroxidation and ferroptosis, regulating immune homeostasis and antitumor immunity. Deletion of Gpx4 can lead to lipid peroxidation and ferroptosis of Treg cells, affecting immune homeostasis and antitumor immunity. Neutralization of lipid peroxides and blockade of iron availability rescue ferroptosis of Gpx4-deficient Treg cells.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

Ling F. Ye et al.

ACS CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

Regina Brigelius-Flohe et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Alexandr A. Kapralov et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Yilong Zou et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Identification of Frataxin as a regulator of ferroptosis

Jing Du et al.

REDOX BIOLOGY (2020)

Article Chemistry, Multidisciplinary

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Vanessa A. N. Kraft et al.

ACS CENTRAL SCIENCE (2020)

Article Medicine, Research & Experimental

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

Kewen Hu et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Liam Baird et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

John K. Eaton et al.

NATURE CHEMICAL BIOLOGY (2020)

Review Cell Biology

Mitochondrial Metabolism as a Target for Cancer Therapy

Karthik Vasan et al.

CELL METABOLISM (2020)

Article Chemistry, Multidisciplinary

Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

Yuqiong Xia et al.

ADVANCED MATERIALS (2020)

Article Biochemistry & Molecular Biology

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Mariluz Soula et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Chemistry, Multidisciplinary

CD44 regulates epigenetic plasticity by mediating iron endocytosis

Sebastian Mueller et al.

NATURE CHEMISTRY (2020)

Article Multidisciplinary Sciences

Lymph protects metastasizing melanoma cells from ferroptosis

Jessalyn M. Ubellacker et al.

NATURE (2020)

Article Multidisciplinary Sciences

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Yilong Zou et al.

NATURE (2020)

Article Multidisciplinary Sciences

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Nandini Verma et al.

SCIENCE ADVANCES (2020)

Review Cell Biology

Iron Metabolism in Ferroptosis

Xin Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Cell Biology

The Metabolic Underpinnings of Ferroptosis

Jiashuo Zheng et al.

CELL METABOLISM (2020)

Article Multidisciplinary Sciences

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

Ji-Yoon Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Junmei Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Oncology

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia Efimova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Letter Biochemistry & Molecular Biology

LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Changzhi Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Oncology

Energy stress inhibits ferroptosis via AMPK

Hyemin Lee et al.

MOLECULAR & CELLULAR ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan et al.

CELL CHEMICAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

The release and activity of HMGB1 in ferroptosis

Qirong Wen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

Javier Garcia-Bermudez et al.

NATURE (2019)

Review Oncology

Targeting Ferroptosis to Iron Out Cancer

Behrouz Hassannia et al.

CANCER CELL (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Article Multidisciplinary Sciences

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

Jonathan K. M. Lim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

Michael D. Arensman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell Biology

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

Wen-Hsuan Yang et al.

CELL REPORTS (2019)

Article Chemistry, Multidisciplinary

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Chen Liang et al.

ADVANCED MATERIALS (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

The chemical basis of ferroptosis

Marcus Conrad et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Cell Biology

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Caitlin W. Brown et al.

DEVELOPMENTAL CELL (2019)

Article Biochemistry & Molecular Biology

Role of Mitochondria in Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Oncology

Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer

Hai-Hong Zhou et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Jose Pedro Friedmann Angeli et al.

NATURE REVIEWS CANCER (2019)

Article Biochemistry & Molecular Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Yan Zhang et al.

CELL CHEMICAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Leslie Magtanong et al.

CELL CHEMICAL BIOLOGY (2019)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Article Biochemistry & Molecular Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold et al.

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Medicine, Research & Experimental

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Cell Biology

Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy

Adam J. Wolpaw et al.

TRENDS IN CELL BIOLOGY (2018)

Article Oncology

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

Jipeng Guo et al.

CANCER RESEARCH AND TREATMENT (2018)

Article Cell Biology

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

Amy Tarangelo et al.

CELL REPORTS (2018)

Article Biochemistry & Molecular Biology

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

Huizhong Feng et al.

PLOS BIOLOGY (2018)

Article Chemistry, Multidisciplinary

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah et al.

ACS CENTRAL SCIENCE (2018)

Article Cell Biology

BAP1 links metabolic regulation of ferroptosis to tumour suppression

Yilei Zhang et al.

NATURE CELL BIOLOGY (2018)

Review Oncology

Targeting mutant p53 for efficient cancer therapy

Vladimir J. N. Bykov et al.

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Oncology

Cancer metabolism: a therapeutic perspective

Ubaldo E. Martinez-Outschoorn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

Delin Chen et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Samantha W. Alvarez et al.

NATURE (2017)

Article Multidisciplinary Sciences

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Review Biochemistry & Molecular Biology

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis

Jonathan A. Stefely et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Article Cell Biology

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Yangchun Xie et al.

CELL REPORTS (2017)

Article Biochemistry & Molecular Biology

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Sally E. Wenzel et al.

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Review Biochemistry & Molecular Biology

The PI3K Pathway in Human Disease

David A. Fruman et al.

Article Oncology

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

Shan Zhu et al.

CANCER RESEARCH (2017)

Article Oncology

Oncogenic role of PDK4 in human colon cancer cells

D. Leclerc et al.

BRITISH JOURNAL OF CANCER (2017)

Article Biochemistry & Molecular Biology

Lipid peroxidation in cell death

Michael M. Gaschler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Article Cell Biology

Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

Article Gastroenterology & Hepatology

Metallothionein-1G Facilitates Sorafenib Resistance Through Inhibition of Ferroptosis

Xiaofang Sun et al.

HEPATOLOGY (2016)

Article Biochemistry & Molecular Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Kenichi Shimada et al.

NATURE CHEMICAL BIOLOGY (2016)

Article Cell Biology

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

Shang-Jui Wang et al.

CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

Article Pharmacology & Pharmacy

DJ-1 as a human oncogene and potential therapeutic target

Ji Cao et al.

BIOCHEMICAL PHARMACOLOGY (2015)

Article Chemistry, Medicinal

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

Marie-Helene Larraufie et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Biochemistry & Molecular Biology

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

Jung Hoon Woo et al.

Article Immunology

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Mai Matsushita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Biochemistry & Molecular Biology

Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang et al.

NATURE (2015)

Article Cell Biology

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

Stephanie M. Robert et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Multidisciplinary Sciences

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson et al.

NATURE (2014)

Review Multidisciplinary Sciences

Mitochondrial form and function

Jonathan R. Friedman et al.

NATURE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Pharmacology & Pharmacy

Glutathione: new roles in redox signaling for an old antioxidant

Katia Aquilano et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Oncology

Unravelling mechanisms of p53-mediated tumour suppression

Kathryn T. Bieging et al.

NATURE REVIEWS CANCER (2014)

Review Biochemistry & Molecular Biology

Glutathione peroxidases

Regina Brigelius-Flohe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Article Oncology

BAP1 and cancer

Michele Carbone et al.

NATURE REVIEWS CANCER (2013)

Review Oncology

A Comprehensive Survey of Ras Mutations in Cancer

Ian A. Prior et al.

CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Multidisciplinary Sciences

Comprehensive genomic characterization of squamous cell lung cancers

Peter S. Hammerman et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

Non-mitochondrial coenzyme Q

D. James Morre et al.

BIOFACTORS (2011)

Article Oncology

Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer

Li Xie et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2011)

Review Oncology

RAS oncogenes: weaving a tumorigenic web

Yuliya Pylayeva-Gupta et al.

NATURE REVIEWS CANCER (2011)

Review Endocrinology & Metabolism

Biochemical and physiological function of stearoyl-CoA desaturase

Chad M. Paton et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

Michael P. Murphy

BIOCHEMICAL JOURNAL (2009)

Article Biochemistry & Molecular Biology

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

Manuela Schneider et al.

FASEB JOURNAL (2009)

Article Biochemistry & Molecular Biology

Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions

Hanyu Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

Hirotaka Imai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Biochemistry & Molecular Biology

Glutathione: Overview of its protective roles, measurement, and biosynthesis

Henry Jay Forman et al.

MOLECULAR ASPECTS OF MEDICINE (2009)

Review Oncology

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

William G. Kaelin

NATURE REVIEWS CANCER (2008)

Article Multidisciplinary Sciences

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

Nicholas Yagoda et al.

NATURE (2007)

Article Cell Biology

Discovery of ubiquinone (coenzyme Q) and an overview of function

Frederick L. Crane

MITOCHONDRION (2007)

Article Biochemistry & Molecular Biology

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Xinjiang Wang et al.

Article Immunology

Glutamate released by dendritic cells as a novel modulator of T cell activation

Rodrigo Pacheco et al.

JOURNAL OF IMMUNOLOGY (2006)

Review Oncology

Divorcing ARF and p53: an unsettled case

Charles J. Sherr

NATURE REVIEWS CANCER (2006)

Review Biochemistry & Molecular Biology

Metabolism and function of coenzyme Q

M Turunen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

Article Biochemistry & Molecular Biology

Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants

M Maiorino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)

SG Moreno et al.

BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

LJ Yant et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Article Biochemistry & Molecular Biology

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

H Sasaki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)