Aseptic Meningitis Following Second Dose of an mRNA Coronavirus Disease 2019 Vaccine in a Healthy Male: Case Report and Literature Review

Article Immunology

Aseptic Meningitis Following the Second Dose of Comirnaty Vaccination in an Adolescent Patient A Case Report

Joon Kee Lee

Summary: This report describes a case of aseptic meningitis occurring 3 weeks after receiving the second dose of Comirnaty vaccine, highlighting the importance of surveillance and management of rare adverse events.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2022)

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Article Immunology

Aseptic meningitis after BNT-162b2 COVID-19 vaccination

Amanda CY. Chan et al.

Summary: The COVID-19 pandemic has significantly impacted global healthcare systems, leading to substantial morbidity and mortality. Vaccination is considered the most crucial strategy in controlling the pandemic. However, concerns have arisen due to sporadic reports of immune-mediated adverse effects. As of August 19, 2021, 4.54 million individuals have been vaccinated against COVID-19 in Singapore. We present a case series of two patients who developed aseptic meningitis after vaccination.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2022)

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Review Medicine, Research & Experimental

COVID-19-associated meningoencephalitis: A care report and literature review

Pu Lv et al.

Summary: Infection with SARS-CoV-2 may affect the central nervous system and lead to various neurological symptoms in patients with COVID-19. Patients diagnosed with COVID-19-associated meningitis/encephalitis show diverse clinical neurological manifestations, with treatment response and prognosis differing among individuals.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Pathology

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein *

Gerard J. Nuovo et al.

Summary: Neurologic complications of symptomatic COVID-19 are commonly seen, with brain tissues from autopsies showing the presence of pseudovirions in endothelial cells. The spike protein was found to induce ACE2+ endothelial damage, highlighting its central role in SARS-CoV2 pathology. Immunohistochemistry for caspase-3 and ACE2 can be used by diagnostic pathologists to document endothelial cell damage in COVID-19.

ANNALS OF DIAGNOSTIC PATHOLOGY (2021)

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Letter Clinical Neurology

Aseptic meningitis after vaccination of the BNT162b2 mRNA COVID-19 vaccine

Kazuyuki Saito et al.

NEUROLOGICAL SCIENCES (2021)

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Review Clinical Neurology

Neurologic Safety Monitoring of COVID-19 Vaccines Lessons From the Past to Inform the Present

Kiran Teresa Thakur et al.

Summary: The global effort to develop effective and safe COVID-19 vaccines in response to the SARS-CoV-2 pandemic is crucial. While vaccines have historically been effective, monitoring and assessing potential safety risks is essential to ensure public health.

NEUROLOGY (2021)

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Article Multidisciplinary Sciences