Related references
Note: Only part of the references are listed.Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism
Xinping Chen et al.
CIRCULATION (2016)
Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function
Corey E. Ventetuolo et al.
EUROPEAN RESPIRATORY JOURNAL (2016)
Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells
Keytam S. Awad et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)
Higher Estradiol and Lower Dehydroepiandrosterone-Sulfate Levels Are Associated with Pulmonary Arterial Hypertension in Men
Corey E. Ventetuolo et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)
PDGF-dependent -catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension
Jack Takahashi et al.
FEBS LETTERS (2016)
BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis
Jonathan D. W. Evans et al.
LANCET RESPIRATORY MEDICINE (2016)
The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1
Anne Katrine Z. Johansen et al.
PULMONARY CIRCULATION (2016)
Neonatal Pulmonary Arterial Hypertension and Noonan Syndrome: Two Fatal Cases with a Specific RAF1 Mutation
Rachel K. Hopper et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2015)
Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis
Ke Yuan et al.
AMERICAN JOURNAL OF PATHOLOGY (2015)
The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension
Alistair C. Church et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)
A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis influences Development of Pulmonary Hypertension
Emma Wallace et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)
Sex Affects Bone Morphogenetic Protein Type II Receptor Signaling in Pulmonary Artery Smooth Muscle Cells
Kirsty M. Mair et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)
Oestrogen receptor alpha in pulmonary hypertension
Audrey F. Wright et al.
CARDIOVASCULAR RESEARCH (2015)
Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension Part I: Metabolic Plasticity and Mitochondrial Dynamics in the Pulmonary Circulation and Right Ventricle in Pulmonary Arterial Hypertension
John J. Ryan et al.
CIRCULATION (2015)
Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series)
Joshua P. Fessel et al.
PULMONARY CIRCULATION (2015)
Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK
Jamie L. Wilson et al.
PLOS ONE (2015)
Sex-Dependent Influence of Endogenous Estrogen in Pulmonary Hypertension
Kirsty M. Mair et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
The Role of Vascular Endothelial Growth Factor in Pulmonary Arterial Hypertension The Angiogenesis Paradox
Norbert F. Voelkel et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)
Targeting the Wnt signaling pathways in pulmonary arterial hypertension
Vinicio de Jesus Perez et al.
DRUG DISCOVERY TODAY (2014)
Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension
Yvonne Dempsie et al.
CARDIOVASCULAR RESEARCH (2013)
Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension Results of the Randomized IMPRES Study
Marius M. Hoeper et al.
CIRCULATION (2013)
Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: Results from the COMPERA registry
Marius M. Hoeper et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)
Pulmonary Arterial Hypertension Epidemiology and Registries
Michael D. McGoon et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension
Joshua P. Fessel et al.
PULMONARY CIRCULATION (2013)
17β-Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor-mediated Effects
Tim Lahm et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
Modern Age Pathology of Pulmonary Arterial Hypertension
Elvira Stacher et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension
Rajkumar Savai et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
Wnt/β-Catenin Signaling and Disease
Hans Clevers et al.
CELL (2012)
Sex Differences in the Diagnosis, Treatment, and Outcome of Patients With Pulmonary Arterial Hypertension Enrolled in the Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management
Shelley Shapiro et al.
CHEST (2012)
Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension
Kevin White et al.
CIRCULATION (2012)
Pulmonary Arterial Hypertension in Patients Treated by Dasatinib
David Montani et al.
CIRCULATION (2012)
BMPR2 expression is suppressed by signaling through the estrogen receptor
Eric D. Austin et al.
BIOLOGY OF SEX DIFFERENCES (2012)
Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation
Jonas Fuxe et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension
I. Morecroft et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension
Kevin White et al.
CARDIOVASCULAR RESEARCH (2011)
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
Vinicio A. de Jesus Perez et al.
JOURNAL OF CELL BIOLOGY (2011)
Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH
Kevin White et al.
PHYSIOLOGICAL GENOMICS (2011)
Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy
Hossein A. Ghofrani et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)
Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension
Elaine Soon et al.
CIRCULATION (2010)
Estrogens and Development of Pulmonary Hypertension: Interaction of Estradiol Metabolism and Pulmonary Vascular Disease
Stevan P. Tofovic
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2010)
Genetic Risk Factors for Portopulmonary Hypertension in Patients with Advanced Liver Disease
Kari E. Roberts et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
The Noncanonical WNT Pathway Is Operative in Idiopathic Pulmonary Arterial Hypertension
Isabel P. Laumanns et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)
Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
E. D. Austin et al.
EUROPEAN RESPIRATORY JOURNAL (2009)
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-β-catenin and Wnt-RhoA-Rac1 pathways
Vinicio A. de Jesus Perez et al.
JOURNAL OF CELL BIOLOGY (2009)
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
Mohamed Izikki et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
Laurent Savale et al.
RESPIRATORY RESEARCH (2009)
Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance
James West et al.
BMC MEDICAL GENOMICS (2008)
Translating insights from development into regenerative medicine: The function of Wnts in bone biology
P. Leucht et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)
EXOGENOUS ESTROGEN RAPIDLY ATTENUATES PULMONARY ARTERY VASOREACTIVITY AND ACUTE HYPOXIC PULMONARY VASOCONSTRICTION
Tim Lahm et al.
SHOCK (2008)
VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells
Seiichiro Sakao et al.
FASEB JOURNAL (2007)
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
M. Abdur Razzaque et al.
NATURE GENETICS (2007)
Integrating signals from RTKs to ERK/MAPK
M. M. McKay et al.
ONCOGENE (2007)
MAP kinase signalling pathways in cancer
A. S. Dhillon et al.
ONCOGENE (2007)
Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
Jared A. Gollob et al.
SEMINARS IN ONCOLOGY (2006)
Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension
RD Machado et al.
HUMAN MUTATION (2006)
Aberrant signal transduction in pulmonary hypertension
KB Lane et al.
CHEST (2005)
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart
J Li et al.
CIRCULATION RESEARCH (2005)
Reversal of experimental pulmonary hypertension by PDGF inhibition
RT Schermuly et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Dysfunctional smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
XD Yang et al.
CIRCULATION RESEARCH (2005)
Abnormal pericyte recruitment as a cause for pulmonary hypertension in Adams-Oliver syndrome
MS Patel et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2004)
Proliferation and signaling in fibroblasts -: Role of 5-hydroxytryptamine2A receptor and transporter
DJ Welsh et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)
Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent
J Widder et al.
CARDIOVASCULAR RESEARCH (2004)
Cellular and molecular pathobiology of pulmonary arterial hypertension
M Humbert et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
PP Roux et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2004)
Overexpression of the 5-hydroxytryptamine transporter gene - Effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension
MR MacLean et al.
CIRCULATION (2004)
A second canon:: Functions and mechanisms of β-catenin-independent wnt signaling
MT Veeman et al.
DEVELOPMENTAL CELL (2003)
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension
N Rudarakanchana et al.
HUMAN MOLECULAR GENETICS (2002)
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
C Atkinson et al.
CIRCULATION (2002)
MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α
BX Ge et al.
SCIENCE (2002)
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
RM Tuder et al.
JOURNAL OF PATHOLOGY (2001)
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction
TM Behr et al.
CIRCULATION (2001)
Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries
DJ Welsh et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
L Taraseviciene-Stewart et al.
FASEB JOURNAL (2001)
Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats
C Partovian et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
JR Thomson et al.
JOURNAL OF MEDICAL GENETICS (2000)