Physiological hormesis and hormetins in biogerontology

Research on the biology of aging and possibilities of interventions has gained a significant push forward by incorporating the concept of mild stress-induced physiological hormesis. Mild stress induced-activation of adaptive and protective pathways in cells and organisms has numerous health promoting, aging-modulatory and lifespan-extending effects. Moderate and repeated physical exercise is the paradigm for physiological hormesis. Molecular mechanisms for the action of hormetins comprise a cascade of primary stress response pathways, including oxidative stress response, heat shock response, unfolded protein stress response, autophagy, DNA damage response, inflammatory response and sirtuin activation response. Hormetin-based strengthening of the organismic ability of homeodynamics or dynamic homeostasis is a promising holistic approach towards health maintenance, recovery, and promotion for healthy aging and longevity.

Automated summary

Research on the biology of aging has progressed by exploring the concept of mild stress-induced physiological hormesis, which activates adaptive and protective pathways in cells and organisms, resulting in health promotion and lifespan extension.