MALVIRUS: an integrated application for viral variant analysis

Editorial Material Multidisciplinary Sciences

Immunity to SARS-CoV-2 variants of concern

Daniel M. Altmann et al.

SCIENCE (2021)

Article Microbiology

Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

Pengfei Wang et al.

Summary: The emerging Brazilian variant P.1 shows increased resistance to antibody neutralization, posing a threat to current antibody therapies, but has less impact on the effectiveness of protective vaccines.

CELL HOST & MICROBE (2021)

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Article Genetics & Heredity

Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women

Maria Monticelli et al.

Summary: The study analyzed the sequence of the TMPRSS2 gene and identified common variants with potentially deleterious effects on the protease activity, particularly p.V197M (p.Val197Met), which showed a protective effect on COVID-19 patients, especially in young males, elderly women, and those with co-morbidities.

GENES (2021)

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Review Genetics & Heredity

Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19

Maria Monticelli et al.

Summary: This study identified genetic variants related to COVID-19 risk factors through text mining and population distribution analysis, revealing associations between five polymorphisms and the number of COVID-19 cases and/or deaths in different countries. The findings suggest a potential role of these genetic variants, particularly in genes related to innate immunity, in individual responses to SARS-CoV-2 infection and the outcome of COVID-19. The results provide a basis for the design of a cost-effective assay for population screening of genetic risk factors during the COVID-19 pandemic.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2021)

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Article Virology

Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool

Aine O'Toole et al.

Summary: The global virus genomics community has responded unprecedentedly to the SARS-CoV-2 pandemic, leading to significant advances in 'real-time' generation and sharing of genomic data. The development of new analytical methods, such as pangolin, has been necessary to handle the rapid growth in virus genome data production. Pangolin has processed nearly two million virus genomes, aiding in SARS-CoV-2 genomic epidemiology and providing researchers with valuable information about the pandemic's transmission lineages.

VIRUS EVOLUTION (2021)

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Article Biochemistry & Molecular Biology