Journal
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
Volume 63, Issue 2, Pages 170-179Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jaclp.2021.09.007
Keywords
Williams syndrome; case series; functional neurological symptom disorder; conversion disorder; pseudoseizure
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This study described the clinical presentation and treatment course of functional neurological symptom disorder (FNSD) in 3 adult patients with Williams syndrome (WS). Literature review revealed a lack of research on the diagnosis and treatment of FNSD in patients with neuro-developmental disorders.
Background: Williams syndrome (WS) is a neuro-developmental disorder associated with several medical and psychiatric comorbidities. Objective: To describe the clinical presentation and treatment course of functional neurological symptom disorder (FNSD) in 3 adult pa-tients with WS. Methods: This report describes the clinical presentation and long-term follow-up of 3 in-dividuals with WS and FNSD who experienced a range of clinical presentations and responses to treatment. The literature on the clinical assessment and treatment of FNSD as it applies to patients with neurodevelopmental disorders is reviewed. Results: FNSD treatment strate-gies used in the general population were successfully adapted for these 3 patients. Literature on the diagnosis and treatment of FNSD in patients with neuro-developmental disorders is lacking. Conclusions: FNSD may be more common in individuals with WS than pre-viously appreciated, and future studies describing the prevalence, clinical presentation, risk factors, and treat-ment of FNSD in WS are needed. (Journal of the Academy of Consultation-Liaison Psy-chiatry 2022; 63:170-179)
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