Journal
VETERINARY SCIENCES
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/vetsci9040172
Keywords
dog; gastric carcinoma; stomach; E-cadherin
Categories
Funding
- FCT [SFRH/BD/116373/2016]
- Portuguese Foundation for Science and Technology
- Portuguese Foundation for Science and Technology (FCT) [UIDB/CVT/00772/2020, LA/P/0059/2020]
- FEDER through the Operational Programme for Competitiveness Factors-COMPETE
- National Funds through the Portuguese Foundation for Science and Technology (FCT) [PEst-C/SAU/LA0003/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/116373/2016] Funding Source: FCT
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This study found that abnormal expression of E-cadherin is associated with canine gastric cancer, and it may play a role in tumor progression and serve as a prognostic tool.
E-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent non-neoplastic mucosa (NNM; n = 32), neoplastic emboli (n = 16) and metastatic lesions (n = 9). The relationship between E-cad expression and clinicopathological features were investigated. In NGM, epithelial cells showed strong latero-lateral membranous expression of E-cad, and this pattern was considered normal. The membranous staining was preserved in all specimens of NNM (100%), whereas abnormal E-cad expression was found in 87.9% of the GCs. A marked difference in E-cad expression was observed between normal and malignant tissues (p < 0.0002). Abnormal E-cad expression was significantly more frequent in poorly/undifferentiated carcinomas (96%) and diffuse (95%) and indeterminate carcinomas (100%) than in well-differentiated/intestinal ones (62.5%; p = 0.0115 and p = 0.0392, respectively). There was significant association between abnormal E-cad expression and the depth of invasion (p = 0.0117), and the presence neoplastic emboli (p = 0.0194). No statistically significant differences in E-cad expression were observed concerning tumor location, histological type according to WHO classification, and presence of metastatic lesions. Therefore, deregulation of E-cad expression may play a role in canine gastric carcinogenesis and in tumor progression; moreover, it might be a prognostic tool for canine gastric cancer.
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